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RNA 5-甲基细胞蛋白修饰:调节分子,生物功能和人类疾病

Yanfang Lu^1,2,3,4, Liu Yang^1,2,3,4, Qi Feng^1,2,3,4

¹Department of Integrated Traditional and Western Nephrology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China.

Genomics, proteomics & bioinformatics

|September 28, 2024

概括

RNA 5-甲基细胞因 (m5C) 修改对基因表达至关重要,并与人类疾病有关. 本综述详细介绍了m5C在健康和疾病中的作用,检测和调节.

科学领域:

表观遗传学在表观遗传学中,表观遗传学是指表观遗传学.
分子生物学分子生物学
基因组学就是基因组学.

背景情况:

RNA甲基化,特别是5-甲基细胞素 (m5C),是影响基因表达的关键表观遗传修饰.
m5C及其相关调节蛋白 (写字器,擦拭器,阅读器) 的失调与众多人类疾病有关.
在各种RNA类型中发现m5C修饰,包括mRNA,tRNA,rRNA和ncRNA,影响它们的功能和稳定性.

研究的目的:

提供关于RNA m5C修饰的最新进展的全面审查.
讨论m5C.的分布,检测方法和监管机制.
突出m5C修饰及其调节器在生物过程和人类疾病病原发生中的重要性.

主要方法:

关于 RNA m5C 修饰的最近研究的文献综述.
综合有关m5C检测技术的信息.
分析有关m5C分销和监管网络的数据.

主要成果:

RNA m5C修饰在调节RNA代谢,稳定性,核出口和翻译方面发挥着至关重要的作用.
m5C调节器在疾病的发展,诊断,预后和治疗中至关重要,包括神经系统疾病和癌症.
最近的进展改善了对m5C检测及其在各种RNA物种中广泛存在的理解.

结论:

RNA m5C 修饰是一种具有广泛生物学意义的显著表观遗传标记.
了解m5C监管网络为疾病诊断,治疗和监测提供了新的途径.
对m5C的进一步研究对于揭示其对人类健康和疾病的全部影响至关重要.

关键词:

生物过程是生物过程.人类疾病人类疾病.通过RNA甲基化.m5C 在线观看在 m5C 调节器上

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