在肺癌的质子疗法期间评估非位器官内的二次癌症风险:蒙特卡洛研究
Sayyed Bijan Jia1, Reza Shamsabadi2, Leili Mogheiseh2
1Department of Physics, University of Bojnord, Bojnord, Iran.
概括
肺癌的质子疗法可能会增加附近器官的二次癌症风险,主要是由于中子辐射. 风险随着瘤深度的增加而增加,但仍然低于基线癌症风险.
科学领域:
- 辐射瘤学 辐射瘤学
- 医学物理 医学物理
- 癌症研究 癌症研究
背景情况:
- 质子疗法提供先进的肺癌治疗.
- 有关二次辐射对非目标器官的影响存在担忧.
- 评估二次癌症风险对于患者安全至关重要.
研究的目的:
- 在肺癌质子疗法期间,评估肺癌外器官中发生二次癌症的风险.
- 量化从二次光子和中子中吸收的剂量.
- 用既有模型估计诱导的二次癌症风险.
主要方法:
- 使用了ICRP 110男性幻影的蒙特卡洛模型.
- 计算了各种瘤部位在场外器官中吸收的剂量.
- 使用BEIR VII和NCRP 116模型估计的二次癌症风险.
主要成果:
- 靠近瘤的器官 (心脏,食道,胸腺,肝脏) 获得了最高相当剂量.
- 相当剂量随着瘤深度 (4-8厘米至12-16厘米) 的增加而增加.
- 中子对总相当剂量的贡献占主导地位 (高达90%).
- 在肝脏和食道中观察到更高的二次癌症风险 (BEIR模型).
- 最大的风险是在左肺 (NCRP 116模型).
- 在这两种模型中,估计的风险随着瘤深度的增加而增加.
- 计算出的风险低于基线癌症风险.
结论:
- 针对肺癌的质子疗法存在于非标器官的二次癌症的风险,受中子辐射的影响.
- 风险取决于瘤的位置和深度,肝脏和食道等器官表现出更高的易感性.
- 虽然风险相对较低,但仔细监测和缓解策略至关重要,以尽量减少长期的二次癌症发展.
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