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孕产妇高BMI:孕产妇和后代压力指数的性别变异

Sameera Abuaish¹, Vanessa Babineau², Seonjoo Lee³

¹Department of Basic Sciences, College of Medicine, Princess Nourah bint Abdulrahman University, P.O.Box 84428, Riyadh 11671, Saudi Arabia.

Psychoneuroendocrinology

|September 28, 2024

概括

母体高体重指数 (BMI) 影响女性胎儿,影响自主神经系统 (ANS) 调节和婴儿行为. 这突显了性别特定的产前编程效应.

科学领域:

生殖健康生殖健康
发育神经科学的发展神经科学.
生理学生理学生理学

背景情况:

孕产妇的体重指数 (BMI) 影响着怀孕的结果和孩子的发育.
胎儿的性别可能会减轻母亲的BMI对发育的影响.
自主神经系统 (ANS) 功能,通过心率 (HR) 和心率变化 (HRV) 进行评估,可以表明产前编程效应.

研究的目的:

检查怀孕前的BMI,母亲和胎儿的ANS功能以及婴儿行为之间的关联.
调查胎儿的性别是否能缓和这些关联.
识别与母亲的BMI相关的产前编程的早期标志物.

主要方法:

孕妇 (N=176) 根据怀孕前的BMI (正常<25,高>25) 分类.
产妇和胎儿HR和HRV在怀孕12-22,23-28和34-36周被评估,包括在第三个三个月的压力因素期间.
婴儿行为被评估在4个月使用婴儿行为问卷-修订.

主要成果:

携带女性胎儿的高BMI妇女在整个妊娠期间表现出更高的HR和更低的HRV.
高BMI母亲的女性胎儿在压力下表现出降低的HRV在妊娠的第三季度.
四个月大的女婴在指导/监管等级上被评为较低的.

结论:

孕前母亲的BMI对母亲的ANS调节有性别特异的编程效应.
这些效应在胎儿在子宫内运作的ANS中很明显.
编程的影响延伸到婴儿早期,影响女婴的神经发育结果.

关键词:

胎儿心率是如何发生的心率变化心率的变化.高的BMI高的BMI是一个问题.婴儿行为婴儿行为怀孕怀孕怀孕怀孕产前编程在产前编程.

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