在健康大脑和儿童发育 (HBCD) 研究中量化大脑发育:磁共振成像和光谱学协议
Douglas C Dean1, M Dylan Tisdall2, Jessica L Wisnowski3
1Department of Pediatrics, University of Wisconsin-Madison, Madison, WI, USA; Department of Medical Physics, University of Wisconsin-Madison, Madison, WI, USA; Waisman Center, University of Wisconsin-Madison, Madison, WI, USA.
Developmental cognitive neuroscience
|September 28, 2024
概括
健康大脑和儿童发育 (HBCD) 研究开发了一种协调的MRI协议,用于早期大脑发育. 这种标准化的方法克服了婴儿和儿童的成像挑战,为了解神经发育创造了一个重要的资源.
科学领域:
- 神经科学是一个神经科学.
- 发展心理学 发展心理学
- 医疗成像医学成像
背景情况:
- 早期的脑部发育至关重要,但用MRI进行研究具有挑战性.
- 现有的神经成像方法在儿科患者群体中面临技术障碍.
- 对于早期神经发育的多地点研究,需要一个标准化的协议.
研究的目的:
- 为健康大脑和儿童发育研究 (HBCD) 建立一个核心,协调的磁共振成像 (MRI) 采集协议.
- 为了使大脑结构,功能,微观结构和代谢物在所有HBCD部位的一致测量.
- 克服儿童神经成像技术方面的技术挑战,用于早期生命发展研究.
主要方法:
- 为27个HBCD研究站点开发了一种协调的MRI协议.
- 在不同的MRI扫描仪平台上匹配获取参数.
- 采用最先进的,运动强大的成像技术,以更快地获取图像.
- 专注于适合年龄的协议和专门的儿科神经成像策略.
主要成果:
- 建立了一个核心的MRI采集协议,用于早期神经发育的多地点纵向研究.
- 初步数据表明,协调协议的可行性和稳定性.
- 该协议有助于测量从出生到幼儿时期的多式联络大脑数据.
结论:
- HBCD MRI 协议为研究早期大脑发育提供了一种标准化,创新的方法.
- 这种资源将使规范神经发育轨迹的评估成为可能.
- 它将支持对发育中的大脑的遗传,生物和环境影响的研究.
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