台湾成年人甲酸盐暴露与功能之间的关系,通过对共变量调整的标准化和累积风险评估来确定
Po-Chin Huang1, Ting-Yi Lin2, Chia-Chao Wu3
1National Institute of Environmental Health Sciences, National Health Research Institutes, Miaoli, Taiwan; Department of Medical Research, China Medical University Hospital, China Medical University, Taichung, Taiwan; Research Center for Precision Environmental Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan.
Ecotoxicology and environmental safety
|September 28, 2024
概括
环境甲酸盐暴露与台湾成年人的功能下降有关. 对特定甲酸盐的更高暴露和累积风险与较低的估计膜过率和较高的专与肌素比率有关.
科学领域:
- 环境健康 环境健康
- 毒理学 毒理学 毒理学
- 腎臟病學 (nephrology) 是一種醫學專業.
背景情况:
- 酸盐暴露很普遍,但它对成年人功能的影响需要进一步调查.
- 对于酸盐-脏功能的研究,同时分析对共变量调整的肌素标准化,累积风险评估和混合物分析是缺乏的.
研究的目的:
- 调查台湾成年人甲酸盐暴露与功能指标之间的关联.
- 应用先进的统计方法,包括对共变量调整的肌素标准化,累积风险评估和混合物分析.
主要方法:
- 来自台湾生物库的839名成年人的横截面研究.
- 测量了10种尿甲酸代谢物,计算了迪布甲 (ΣDBPm) 和二-2-乙烯) 甲 (ΣDEHPm) 的总和.
- 使用BUN,尿酸,ACR和eGFR评估功能;采用通用线性模型和贝叶斯核机器回归 (BKMR).
主要成果:
- 在 ΣDEHPm 和 BUN/ACR,以及 ΣDBPm 和 ACR 之间发现了积极的关联.
- 在 ΣDBPm, ΣDEHPm 和 eGFR 之间观察到负相关性.
- BKMR揭示了酸盐混合物与BUN,尿酸,ACR和eGFR之间的显著关联.
结论:
- 环境甲酸盐暴露与台湾成年人的功能受损有关.
- 特定酸盐 (DEHP,DnBP,DiBP,DEP) 和累积风险 (HI) 与不良的功能标志物有关.
- 研究结果强调了减少甲酸盐暴露以保护脏健康对公共卫生的重要性.
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