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Updated: Jun 11, 2025

High-throughput Antiviral Assays to Screen for Inhibitors of Zika Virus Replication
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使用核磁共振和RosettaMP对寨卡病毒NS2B的结构和动态表征:跨膜蛋白研究的挑战

Beatriz R Penna1, Francisco Gomes-Neto2, Cristiane D Anobom3

  • 1Institute of Medical Biochemistry (IBqM), Federal University of Rio de Janeiro, Rio de Janeiro, Brazil; National Center of Nuclear Magnetic Resonance (CNRMN), Center for Structural Biology and Bioimaging (CENABIO), Federal University of Rio de Janeiro, Rio de Janeiro, Brazil.

International journal of biological macromolecules
|September 28, 2024
PubMed
概括

研究人员阐明了寨卡病毒NS2B蛋白的结构,这是病毒复制的关键因素. 这一发现有助于开发新的抗病毒药物来对抗寨卡病毒感染.

关键词:
在NS2B中,它是NS2B.核磁共振 (NMR) 是一种核磁共振技术.蛋白质动态 蛋白质动态蛋白质结构 蛋白质结构罗塞塔MP 罗塞塔MP 罗塞塔MP寨卡病毒 (ZIKV) 病毒

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¹H NMR of Conformationally Flexible Molecules: Temporal Resolution00:52

¹H NMR of Conformationally Flexible Molecules: Temporal Resolution

At room temperature, the chair conformer of cyclohexane undergoes rapid ring flipping between two equivalent chair conformers at a rate of approximately 105 times per second. These two chair conformers are in equilibrium. The rapid ring flipping results in the interconversion of the axial proton to an equatorial proton and an equatorial to the axial proton. Such interconversions are too rapid and cannot be detected on the NMR timescale. Hence, the NMR spectrometer cannot distinguish between the...
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