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Updated: Jun 11, 2025

Preparation and Characterization of Individual and Multi-drug Loaded Physically Entrapped Polymeric Micelles
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长期控制释放的制备和释放模式研究 布隆纳塞林微球

Xiangqin Chen1, Shengnan Qiu1, Yanbin Shi2

  • 1Key Laboratory for Technology Research and Evaluation of Drug Products, School of Pharmaceutical Sciences, Cheeloo College of Medience, Shandong University, 44 Wenhuaxi Road, Jinan, Shandong Province, 250012, China.

International journal of pharmaceutics
|September 28, 2024
PubMed
概括

这项研究使用混合分子量PLGA开发了Blonanserin微球,实现了接近零的释放模型,没有滞后阶段. 优化的配方可确保长达35天的持续抗精神病药物输送.

关键词:
这就是Blonanserin.时间滞后时间滞后.微流体技术的微流体技术微球是微球的组成部分.PLGA混合物是一种混合物.精神分裂症的精神分裂症患者.

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Factors Affecting Dissolution: Particle Size and Effective Surface Area01:23

Factors Affecting Dissolution: Particle Size and Effective Surface Area

Dissolution kinetics, an essential aspect of oral drug delivery, is significantly influenced by the drug's particle size. According to the Noyes-Whitney dissolution model, the dissolution rate correlates directly with the drug's surface area. The larger the surface area, the higher the drug's solubility in water, leading to a faster drug dissolution rate. Reducing particle size increases the effective surface area, enhancing the dissolution process. Micronization and nanosizing are...
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