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在子宫内对新生儿的美微生物群的多环芳暴露的评估

Divya Keerthy¹, Miranda J Spratlen², Lingsheng Wen³

¹Neonatal and Perinatal Medicine, Columbia University, New York, NY, United States; Neonatal and Perinatal Medicine, NewYork Presbyterian Queens, Flushing, NY, United States.

Environmental research

|September 28, 2024

概括

产前暴露于多环芳 (PAHs) 可能会破坏新生儿发育中的肠道微生物群. 高水平的PAH暴露对肠道微生物多样性产生了负面影响,这表明可能会对早期殖民造成干扰.

科学领域:

环境健康环境健康
微生物学微生物学
发育毒理学发展毒理学

背景情况:

在子宫内暴露于环境中的多环芳 (PAH) 与不良的神经发育结果,早产和低出生体重有关.
肠道微生物群作为宿主和环境之间的关键接口,使其成为PAH引起的健康影响的潜在调解者.
了解产前PAH暴露对婴儿肠道微生物群的影响对于阐明疾病途径至关重要.

研究的目的:

为了研究在子宫中多环芳 (PAH) 暴露对新生儿微生物组的组成和多样性的影响.
探索不同水平的产前PAH暴露和肠道微生物α和β多样性的测量之间的关联.
为了确定与产前PAH暴露有关的不同丰富的特定细菌种群.

主要方法:

从公平开始分娩队伍中分析了49个具有满期分娩的母婴二合体和充足的样本.
使用个人活跃采样器在怀孕第三个三个月期间测量产前PAH暴露.
微生物群多样性 (alpha和beta) 和35个基于PAH暴露三角体 (高与低/中等) 的35个样本中的不同种群丰度的评估.

主要成果:

虽然总PAH暴露没有显著改变α多样性,但特定的PAH显示出不同的关联. 对[a] (BaA) 和 (Chry) 的高暴露与α多样性有负相关,而对[a] (BaP) 的低/中等暴露显示出正相关.
在对出生体重和性别进行调整后,高暴露于BaA,BaP,Chry,indeno[1,2,3-cd]pyrene (IcdP) 和总PAHs与α多样性指标有负相关性.
没有发现贝塔多样性的显著差异,但差异丰度分析显示,特定的细菌种群在暴露组之间有所不同.

结论:

在子宫内暴露PAH似乎会改变肠道微生物群的α多样性和细菌种群的丰富性,这表明早期微生物殖民的潜在障碍.
尽管样本规模有限,但这些发现提供了初步证据,支持对产前PAH暴露的长期健康影响进行更大规模研究的需要.
需要进一步的研究,以阐明特定的PAH对婴儿肠道微生物组的不同影响以及随后的健康结果.

关键词:

空气污染物空气污染物空气污染大气污染麦科尼的微生物群.新生儿新生儿新生儿新生儿多循环芳香碳化合物多循环芳香碳化合物产前暴露在产前暴露.

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