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评估PD-L1表达在PBRM1-改变的透明细胞细胞癌中

Jieun Lee¹, Seyoung Moon¹, Hyun Jung Kwon²

¹Department of Pathology, Seoul National University Bundang Hospital, Seongnam-si, Gyeonggi-do, Republic of Korea.

Urologic oncology

|September 28, 2024

概括

具有PBRM1变化的清细胞细胞癌 (ccRCC) 经常显示PD-L1表达,影响免疫治疗反应. PBRM1的改变可能会使PD-L1免疫组织化学 (IHC) 复杂化,作为ccRCC治疗的预测标志物.

科学领域:

在瘤学瘤学.
分子生物学分子生物学
免疫治疗是一种免疫疗法.

背景情况:

清细胞细胞癌 (ccRCC) 经常表现出多基1 (PBRM1) 变化.
PBRM1的变化与免疫检查点阻塞的反应有关,包括ccRCC中的抗编程细胞死亡1 (PD1) /编程细胞死亡连接体1 (PD-L1) 治疗.

研究的目的:

调查PBRM1变化与ccRCC中的PD-L1表达之间的关联.
评估PBRM1变化的潜力,作为PD-L1阻塞治疗的预测标记.

主要方法:

在局部化ccRCC中使用免疫组织化学 (IHC) 分析PBRM1和PD-L1表达 (第1队列,n=526).
下一代测序 (NGS) 和IHC用于高级ccRCC中PBRM1变化的测序 (2队列,n=59).
对PBRM1变化,PD-L1表达和瘤复发之间的相关性分析.

主要成果:

PD-L1阳性与局部ccRCC中PBRM1表达的丧失显著相关 (P < 0.001).
失去PBRM1表达和PD-L1表达与增加瘤复发相关.
在先进的ccRCC中,PBRM1 IHC与NGS具有很高的一致性 (灵敏度84.48%,特异性87.5%).
在晚期ccRCC中没有发现PBRM1突变和PD-L1表达之间的显著相关性,但60%的PBRM1-改变病例是PD-L1阳性.

结论:

虽然没有确定PBRM1突变和PD-L1表达之间的直接相关性,但PBRM1-改变的ccRCC经常与PD-L1表达同时发生.
对于使用PD-L1 IHC作为ccRCC中PD-L1阻塞治疗的唯一预测标记物来说,PBRM1的改变可能会带来挑战.

关键词:

22C3 一个有趣的故事免疫治疗是一种免疫疗法.这是下一代测序.这就是PBRM1的原因.编程细胞死亡配体1 编程细胞死亡配体1 细胞癌是细胞癌.

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