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具有长期肠保留的三级胰岛素水凝,用于同时逆转IBD及其纤维化并发症
Xiangjing Cao1, Shi Tao1, Weitao Wang1
1School of Food and Biological Engineering, Hefei University of Technology, Hefei, 230009, China.
Nature communications
|September 28, 2024
概括
这项研究开发了一种结合益生菌,纳米酶和抗纤维素药物的新型水凝,用于同时治疗炎症性肠病 (IBD) 和肠纤维化. 在小鼠模型中,PPy/PFD@Inulin凝有效降低了炎症,修复了肠道屏障,并逆转了纤维化.
科学领域:
- 生物材料科学 生物材料科学
- 胃肠病学 胃肠病学
- 纳米技术 纳米技术
背景情况:
- 炎症性肠病 (IBD) 的特点是过度反应性氧和物种 (RONS) 和肠道微生物群失调,往往导致肠道纤维化.
- 目前的治疗方法难以同时解决IBD及其纤维化并发症.
研究的目的:
- 开发一种新型的益生菌胰岛素水凝,载有多 (PPy) 纳米酶和皮尔芬 (PFD),用于同时改善IBD和肠道纤维化.
- 在IBD和纤维化病的临床前模型中研究这种工程水凝的治疗疗效.
主要方法:
- PPy/PFD@Inulin凝在急性和慢性结肠炎和肠纤维化诱导的小鼠模型中口服.
- 评估RONS清理,肠道微生物群调节,肠道上皮质屏障修复和TGF-β/Smad信号通路.
- 对大肠炎和纤维化病的预防和治疗作用的评估.
主要成果:
- 胰岛素凝延长了PPy纳米酶和PFD在胃肠道中的停留时间.
- PPy/PFD@胰岛素凝显著降低了促炎性细胞因子,增强了屏障修复,并抑制了肠道纤维化.
- 治疗有效调节了肠道微生物群,减弱了TGF-β/Smad通路,抑制了纤维细胞的增殖.
结论:
- 设计的PPy/PFD@Inulin凝在IBD和相关肠道纤维化中显示出显著的预防和治疗疗效.
- 这种三元水凝提供了一种开创性的单疗法方法,可以同时逆转IBD及其纤维化并发症.
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