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Updated: Jun 11, 2025

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表观遗传阅读器ZMYND11非正规功能限制了HNRNPA1介导的压力颗粒形成和瘤活性

Cheng Lian1, Chunyi Zhang1, Pan Tian1

  • 1Fudan University Shanghai Cancer Center & MOE Key Laboratory of Metabolism and Molecular Medicine and Department of Biochemistry and Molecular Biology of School of Basic Medical Sciences, and Institutes of Biomedical Sciences, Shanghai Medical College, Fudan University, Shanghai, China.

Signal transduction and targeted therapy
|September 28, 2024
PubMed
概括

含有MYND类型的指11 (ZMYND11) 通过结合甲基化HNRNPA1作为瘤抑制剂,防止癌细胞生长. 抑制破坏这种相互作用的PRMT5显示出治疗ZMYND11低癌症的前景.

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