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Updated: Jun 11, 2025

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p21通过DREAM/MMB/Rb-E2F1调节Wnt-Notch平衡,并维持肠干细胞平衡

Liangxia Jiang1, Jie Tian1, Jun Yang1

  • 1Department of Pathophysiology, School of Basic Medicine, Guizhou Medical University, Guiyang, Guizhou, China.

Cell death discovery
|September 28, 2024
PubMed
概括

失去p21功能会破坏Wnt-Notch信号传递,导致肠道干细胞丧失和加速衰老. 恢复p21功能可以维持干细胞平衡和Wnt-Notch平衡.

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