碳水化合物抗原19-9与发生型2型糖尿病之间的性别特异关联
Sujeong Shin1, Yoosoo Chang2,3,4, Seungho Ryu5,6,7
1Department of Family Medicine, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, South Korea.
高碳水化合物抗原19-9 (CA19-9) 水平预测男性患2型糖尿病 (T2D) 的风险更高,但女性没有. 这一发现表明基于CA19-9水平的T2D性别特异性风险评估.
科学领域:
- 内分泌学 在内分泌学.
- 癌症生物标志物 癌症生物标志物
- 糖尿病研究研究 糖尿病研究
背景情况:
- 碳水化合物抗原19-9 (CA19-9) 与血糖控制和2型糖尿病 (T2D) 的并发症有关.
- 在女性中观察到较高的CA19-9水平,尽管男性的T2D患病率更高.
- 需要调查CA19-9和T2D发病率之间的性别相关联.
研究的目的:
- 检查CA19-9水平与T2D发病率之间的纵向性关系.
- 确定CA19-9是否可以以性别依赖的方式作为T2D风险的预测生物标志物.
主要方法:
- 分析了一大批没有癌症或T2D的韩国成年人 (n=329,380).
- 根据基线CA19-9水平,参与者被分为四组.
- 考克斯的比例危险模型评估了CA19-9水平和T2D事件之间的时间依赖关联,平均随访时间为6.1年.
主要成果:
- 男性的T2D发病率 (9.9/1000人年) 比女性 (3.6/1000人年) 高.
- 在男性中,CA19-9水平升高 (≥10.0 U/mL) 与T2D风险增加显著相关 (HRs在1.08至1.64之间).
- 在女性中,CA19-9水平和T2D发病率之间没有显著的关联 (P相互作用=0.006).
结论:
- 升高的CA19-9水平是男性发生T2D的重要预测因素,但不是女性.
- CA19-9可以作为一个有价值的,特定于性别的生物标志物,用于识别患T2D高风险的男性.
- 对于CA19-9升高的未来风险分层和评估策略应该考虑性别差异.
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