在COVID-19住院患者中,临床表现,全身炎症反应和ANDC得分
Jung Lung Hsu1,2,3,4, Mei-Chuen Liu5, Po-Wei Tsau6
1Department of Neurology, New Taipei Municipal TuCheng Hospital (Built and Operated by Chang Gung Medical Foundation, New Taipei City, Taiwan. tulu@ms36.hinet.net.
Scientific reports
|September 28, 2024
概括
在COVID-19患者中,无氧性/老年性与年轻的年龄,较低的炎症和更好的结果有关. 该ANDC得分有效预测住院时间,有助于严重程度的评估.
科学领域:
- 传染性疾病 传染性疾病
- 病毒学 病毒学
- 内部医学 内部医学
背景情况:
- 无呼吸症/老年症是SARS-CoV-2感染的已知的症状.
- 了解COVID-19患者的临床特征和炎症标志物至关重要.
研究的目的:
- 研究台湾住院COVID-19患者的临床特征和全身炎症.
- 为了分析 anosmia/ageusia 与疾病严重程度和炎症标志物的关联.
主要方法:
- 对231名住院COVID-19 (阿尔法变种) 患者进行了回顾性观察性研究.
- 对临床症状,呼吸障碍分级,中性粒细胞-淋巴细胞比率 (NLR),血小板-淋巴细胞比率 (PLR) 和ANDC分数的分析.
- 多变量回归分析以确定显著的关联.
主要成果:
- 无氧性/老年性发生在9%的患者中,与年轻的年龄,较低的BMI,减少的炎症和更好的ANDC得分有关.
- 女性患者的NLR和ANDC得分较低.
- 与CRP和费里丁相关联的NLR;与ESR和费里丁相关联的PLR. ANDC的得分预测了住院时间.
结论:
- 在COVID-19中,无氧症/老年症可能表明疾病不那么严重,炎症反应较低,特别是在年轻和女性患者中.
- ANDC评分是预测COVID-19患者结果和住院时间的有价值的预后工具.
- 临床表现和炎症概况与西方人群相似,尽管在厌氧症/老年症患病率上存在种族差异.
相关概念视频
Endocarditis II: Clinical features and Diagnostic Tests
2
Endocarditis can present various clinical features depending on the causative organism and the patient's underlying health conditions. Initially, the clinical features of infective endocarditis develop gradually, presenting with nonspecific symptoms that can be easily mistaken for other illnesses.General SymptomsEarly symptoms of infective endocarditis are fever, chills, weakness, malaise, fatigue, and weight loss. These symptoms reflect the systemic nature of the infection and the body's...
2
Myocarditis II: Clinical features and Diagnostic Tests
2
Myocarditis is an inflammation of the heart muscle. The symptoms vary widely, encompassing asymptomatic presentations to severe, acute manifestations.Clinical PresentationAsymptomatic cases: In some instances, myocarditis may be asymptomatic, with the infection resolving without intervention. These cases often go undetected unless discovered incidentally through diagnostic imaging or tests conducted for other reasons.General Early Symptoms: Early symptoms of myocarditis are non-specific and can...
2
Pericarditis II: Clinical features and Diagnostic Tests
3
Pericarditis is distinguished by inflammation of the pericardium, the fibrous sac that encases the heart. It can be acute, lasting less than six weeks, or chronic, persisting for over three months. Understanding its clinical manifestations and diagnostic findings is crucial for timely and effective management.Clinical ManifestationsWhile pericarditis can be asymptomatic, it usually presents with characteristic symptoms such as:Chest Pain: The most characteristic symptom of pericarditis is chest...
3
Inflammatory Response I: Vascular and Cellular
11.0K
The inflammatory response is the body's defense against infection, injury, or irritation from bacteria, trauma, toxins, or heat. Inflammation helps locate and destroy pathogens and remove damaged tissue elements to heal the body. During this initial phase, fluid, blood products, and nutrients migrate to the injured area, resulting in redness, heat, swelling, ache, and loss of function. Moreover, signs of systemic inflammation include fever, increased WBC count, malaise, anorexia, nausea,...
11.0K
Pneumonia III: Complications and Assessment
182
Pneumonia poses the potential for numerous complications that warrant consideration. These complications include the following:
182
Pneumonia II: Pathophysiology
229
The pathophysiology of pneumonia involves the following steps:
229


