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瑞斯德罗纳特可以预防运动引起的高热血症,但不能预防恶心或吐:一项双盲随机对照试验
Masamitsu Senda1,2, Naohiko Fujii3, Toshimitsu Ito2
1Health Care Division, Health and Counseling Center, Osaka University, Osaka, Japan.
Scientific reports
|September 28, 2024
概括
这项研究发现,瑞塞德酸盐通过抑制骨再吸收来减少运动后的高血症,但并没有缓解恶心或吐. 这表明高血症是运动引起的恶心的后果,而不是原因.
科学领域:
- 运动生理学 运动生理学
- 骨的新陈代谢 骨的新陈代谢
- 药理学 药理学是指药理学的学科.
背景情况:
- 运动后的恶心和吐与血中水平升高和骨再吸收增加有关.
- 了解运动,代谢和胃肠道疾病之间的关系对于运动员的健康至关重要.
研究的目的:
- 为了研究二酸盐对运动后水平和相关症状的影响.
- 确定瑞塞德龙酸能否减轻运动引起的高血症及其与恶心或吐的潜在联系.
主要方法:
- 一个随机,双盲,安慰剂对照试验,涉及104名健康男性进行重度运动.
- 参与者在5小时的运动课程之前接受了RISEDRONATE (17.5毫克) 或安慰剂.
- 评估了主要结果 (恶心/吐严重程度) 和次要结果 (血清,骨再吸收标志物,热病症状).
主要成果:
- 瑞斯德罗纳特显著降低了运动后血清总 (tCa),电离 (iCa) 和耐酸酸酶5b (TRACP-5b) 的水平.
- 运动后高血症的发生率和尿路/的比率在RISEDRONATE组明显较低.
- 尽管存在生物化学变化,但两组之间没有观察到恶心或吐严重程度的显著差异.
结论:
- 瑞斯德罗纳特通过抑制骨再吸收,有效地减少运动后的高血症.
- 运动后高血症似乎是运动引起的恶心或吐的结果,而不是原因.
- 双酸盐可能在强度体力活动后的代谢障碍的管理中发挥作用.
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