门静脉气体的值和预测重症新生儿死性肠球炎的诺莫图
Yixian Chen1,2, Yuhui Duan3, Ba Wei4
1Department of Pediatrics, The Second Affiliated Hospital of Guangxi Medical University, Guangxi, China.
Pediatric research
|September 28, 2024
概括
门静脉气 (PVG) 与新生儿死性肠球炎 (NEC) 的风险增加有关. 使用PVG和其他因素的新名录模型有助于早期识别和治疗重度NEC的治疗计划.
科学领域:
- 新生儿科学 新生儿科学
- 儿科手术 儿科手术
- 医疗成像医学成像
背景情况:
- 门静脉气体 (PVG) 是新生儿死性肠球炎 (NEC) 的一个公认的成像发现.
- 预后意义和PVG与严重NEC结局的关联仍在争论中.
- 关于PVG作为NEC手术干预指标存在不确定性.
研究的目的:
- 调查PVG和严重NEC结果之间的关联.
- 开发和验证严重NEC的预测模型.
- 评估用于早期NEC管理的PVG纳入的诺米图的临床实用性.
主要方法:
- 使用LASSO和多变量逻辑回归来开发一个预测性名ogram模型.
- 来自两个医疗中心的培训和验证套件.
- 使用曲线下的面积 (AUC),校准曲线和决策曲线分析 (DCA) 的模型评估.
主要成果:
- 患有PVG的患者表现出更高的手术干预或死亡风险.
- 建立了一个结合PVG,侵入性机械通风 (IMV),血小板计数 (PLT) 和pH<7.35的预测模型.
- 该模型表现出适度的预测值 (AUC>0.8),校准良好,临床效用良好.
结论:
- PVG是严重NEC的重要危险因素.
- 开发的nomogram模型,整合PVG和其他临床变量,有助于早期识别严重的NEC.
- 这个工具可以帮助医生制定适时和适当的治疗策略,为新生儿与NEC.
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