与代谢功能障碍相关的脂肪性肝病和胆囊多的发展:一项观察性研究
Masahiro Sogabe1,2, Toshiya Okahisa3,4, Miwako Kagawa4
1Department of Gastroenterology and Oncology, Tokushima University Graduate School of Biomedical Sciences, 3-18-15 Kuramoto-cho, Tokushima, Tokushima, 770-8503, Japan. sogabe.masahiro@tokushima-u.ac.jp.
Scientific reports
|September 28, 2024
概括
与代谢功能障碍相关的脂肪性肝病 (MASLD) 与胆囊息肉发育没有直接相关. 然而,患有多个MASLD成分的患者患病风险增加,需要密切监测,特别是患有晚期疾病的男性.
科学领域:
- 肝病学和胃肠病学 肝病学和胃肠学
- 代谢健康 代谢健康
- 消化系统疾病研究研究
背景情况:
- 代谢功能障碍相关的肥胖性肝病 (MASLD) 和胆囊聚体形成之间的关系尚不清楚.
- 现有的研究缺乏关于MASLD对不同性别胆囊多发育的影响的纵向数据.
研究的目的:
- 调查MASLD与胆囊多的发展之间的纵向关联.
- 为了澄清MASLD在大量患者队列中的胆囊多基生中的作用.
主要方法:
- 一项观察性研究包括5527名没有先前胆囊息肉的患者,在两年多的时间内进行多次健康检查.
- 用通用估计方程来分析重复测量MASLD和胆囊息肉发育的情况.
主要成果:
- 胆囊聚的发病率在男性中为7.5%,在女性中为5.6% (p < 0.01).
- 马斯尔德本身与胆囊息肉的发展没有显著的相关性.
- 具有四个或更多MASLD成分的男性和女性患胆囊多的几率显著更高 (OR分别为3.397和5.338).
- 较高的非酒精性脂肪肝纤维化得分与女性胆囊多风险增加有关 (OR 1.991).
结论:
- 虽然MASLD与胆囊息肉的直接联系很弱,但MASLD成分的数量是一个重要的风险因素.
- 对于越来越多的MASLD组件患者,特别是患有晚期疾病的男性,密切监测胆囊息肉至关重要.
相关概念视频
01:26Diseases of the Liver and Gallbladder
485
Liver and gallbladder diseases are a significant health concern, with prominent conditions including cirrhosis, hepatitis, non-alcoholic fatty liver disease (NAFLD), and gallstones. Jaundice is a common manifestation of liver and biliary disease.
Cirrhosis is characterized by the scarring of hepatic lobules in the liver, which are replaced by fibrous tissue, affecting the liver's normal functioning. NAFLD, on the other hand, is caused by an excessive build-up of fat in the liver, not...
Cirrhosis is characterized by the scarring of hepatic lobules in the liver, which are replaced by fibrous tissue, affecting the liver's normal functioning. NAFLD, on the other hand, is caused by an excessive build-up of fat in the liver, not...
485
01:29Chronic Pancreatitis II: Collaborative Care
70
The management of chronic pancreatitis is multifaceted, involving a comprehensive approach that includes thorough assessment, diagnostic testing, and a variety of management strategies.
Assessment:
Assessment:
70
01:24Chronic Pancreatitis I: Introduction
76
The pancreas, an elongated and flat gland situated behind the stomach, serves a vital function in digesting food and managing blood sugar levels.
Pancreatitis is the inflammation of the pancreas, which occurs when the immune system becomes active and causes swelling, pain, and disruptions in organ function. Pancreatitis can manifest as either an acute or chronic condition.
Acute pancreatitis arises suddenly and lasts for a brief duration, while chronic pancreatitis is a long-term affliction...
Pancreatitis is the inflammation of the pancreas, which occurs when the immune system becomes active and causes swelling, pain, and disruptions in organ function. Pancreatitis can manifest as either an acute or chronic condition.
Acute pancreatitis arises suddenly and lasts for a brief duration, while chronic pancreatitis is a long-term affliction...
76
01:24Overview of Lipid Metabolism
1.1K
Lipid metabolism is a crucial process in the human body that involves the synthesis and degradation of lipids. This process is essential for energy production, cell membrane formation, and hormone production, among other functions.
Lipolysis: The Breakdown of Lipids:
Lipolysis is the process of breaking down lipids, particularly triglycerides, into glycerol and fatty acids. This process typically occurs in the adipose tissue and is triggered by various hormones, including glucagon and...
Lipolysis: The Breakdown of Lipids:
Lipolysis is the process of breaking down lipids, particularly triglycerides, into glycerol and fatty acids. This process typically occurs in the adipose tissue and is triggered by various hormones, including glucagon and...
1.1K