在怀疑新生儿败血症的婴儿中采集的血量用于培养
Maria S Rueda1, Lamia Soghier2,3, Joseph Campos3,4,5,6
1Division of Pediatric Infectious Diseases, University of Alabama at Birmingham, Birmingham, AL, USA. mruedaaltez@uabmc.edu.
概括
新生儿血液培养量通常符合建议,但夜间采集的产量较低. 在败血症诊断之间,样本体积没有差异,这表明它们不应该决定抗生素的持续时间.
科学领域:
- 新生儿医学 新生儿医学
- 临床微生物学 临床微生物学
- 儿童传染病 儿童传染病
背景情况:
- 准确的血液培养量对于诊断新生儿败血症至关重要.
- 影响新生儿重症监护室 (NICU) 样本充分性的因素需要进行调查.
- 了解败血症诊断类别之间的体积差异对于治疗指南很重要.
研究的目的:
- 为了评估新生儿的血液培养样本体积.
- 为了确定与血液培养量不足相关的因素.
- 为了比较新生儿的样本量与培养负性败血症,败血症排除和血液感染 (BSI).
主要方法:
- 在NICU住院期间收集的血液培养的观察性队列研究.
- 使用后勤回归来识别与低于推量相关的因素 (年龄,体重,性别,来源,收集时间).
- 差异分析 (ANOVA) 在不同败血症诊断组中比较血液培养注射剂.
主要成果:
- 总共分析了来自292名新生儿的742种血液培养物.
- 中位数注射液体体积为1毫升,其中35%的瓶子含量低于推的0.9毫升.
- 夜班采集与较低的样本量有显著的关联 (p=0.006).
结论:
- 在NICU中,血液培养体积的中位数符合当前的建议.
- 夜班采集与减少的样本量有关.
- 在培养负性败血症,败血症排除和BSI的新生儿之间,样本体积没有显著差异,表明样本体积不应证明长期抗生素治疗是合理的.
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