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Updated: Jun 11, 2025

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DRCTdb:与疾病相关的细胞类型分析来解码细胞类型效应和潜在的监管机制

Yunhui Kong1,2, Junyao Jiang3, Weikang Kong4

  • 1Jiangsu Key Laboratory of Sericultural Biology and Biotechnology, School of Biotechnology, Jiangsu University of Science and Technology, Zhenjiang, China.

Communications biology
|September 28, 2024
PubMed
概括

疾病相关细胞类型数据库 (DRCTdb) 将遗传变异与涉及疾病的特定细胞类型联系起来. 该资源有助于通过整合全基因组关联研究 (GWAS) 和单细胞数据来理解疾病机制.

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Embryonic and induced pluripotent stem cells are excellent models for disease research because of their ability to self-renew and differentiate into most cell types. Somatic cells from a patient are isolated and reprogrammed into induced pluripotent stem cells or iPSCs. These iPSCs are later differentiated into the desired cell type, which mirrors the diseased cell of the patient. In this way, disease models have been created for investigating diseases such as Down syndrome, type I diabetes,...
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