通过常规和添加剂制造的单一制造商的状的比较分析
Harry Hothi1,2, Johann Henckel3, Arya Nicum4
1The Royal National Orthopaedic Hospital, Stanmore, HA7 4LP, UK. harry.hothi@nhs.net.
3D printing in medicine
|September 28, 2024
概括
与传统制造的Trident I相比,3D打印的Trident II乙烯基骨外在质量,粗度,墙壁厚度和结构空隙方面存在显著差异. 这些发现对于了解新型3D打印外的性能至关重要.
科学领域:
- 整形外科手术 整形外科手术
- 生物材料工程 生物材料工程
- 增材制造 增材制造 增材制造
背景情况:
- 三叉 II 乙烯基体外是增材制造的 (3D 打印).
- 它基于已建立的Trident I Tritanium外,使用常规方法生产.
- 这项研究描述了这两种类型之间的差异.
研究的目的:
- 为了比较3D打印的三二号甲骨外与传统制造的三一号外的物理和结构特性.
- 提供数据,以帮助解释三叉II外的临床性能.
主要方法:
- 获得了五个不同尺寸 (52毫米,54毫米,60毫米) 的三叉I (T1) 和五个三叉II (T2) .
- 测量包括质量,外外接触表面粗度,圆度,墙壁厚度,多孔层深度,多孔度和结构空隙.
主要成果:
- 与三叉号I相比,三叉号II弹在质量,内部粗度 (0.43微米与0.18微米) 和偏离圆度 (8.9微米与6.9微米) 上有显著差异.
- T2外壁较薄 (54毫米和60毫米尺寸分别为37%和29%).
- T2外具有不规则的,较浅的多孔结构,结构空洞数量明显高 (115-3415) 比T1外 (21-31).
结论:
- 这是第一项比较使用传统方法和添加方法生产的单一制造商的乙骨的研究.
- 3D打印的Trident II外的特征差异对于解释其在临床数据出现时的性能很重要.
- 这些发现凸显了对3D打印骨科植入物持续评估的需要.
相关概念视频
01:24Characteristics and Nomenclature of Copolymers
2.7K
Copolymers are the products obtained from the polymerization of multiple monomer species. So, in a polymer chain itself, there can be multiple repeating units that come from different monomers. The process of synthesizing a polymer from different monomer species is called copolymerization. When two monomers are involved, the polymer is known as a bipolymer. Polymers with three and four monomers are termed terpolymers and quaterpolymers, respectively. Figure 1 depicts the copolymerization of...
2.7K
01:14Drug Dissolution: Requirements and Profile Comparison
500
The acceptance criteria for dissolution profile data are anchored in Q values, representing the percentage of drug dissolved within a specified period. This assessment unfolds in three stages:First Stage: The test passes if all six drug dosage units are equal to or greater than Q plus 5%; otherwise, the sample proceeds to the second stage.Second Stage: The average of twelve units must be equal to or greater than Q, with no unit falling below Q - 15% to pass; if not, it progresses to the final...
500
01:27Pharmaceutical Alternatives: Polymorphic Form-Related and Particle Size-Related Therapeutic Nonequivalence
226
Changes in polymorphic forms can significantly influence the bioavailability of poorly soluble drugs. Although the FDA defines pharmaceutical equivalence based on having the same active ingredient, dosage form, and route of administration, it does not automatically disqualify products with different polymorphic forms. This means two products with different polymorphs can still be deemed pharmaceutically equivalent. However, polymorphic differences can affect properties like wettability,...
226
01:18Formulation and Manufacturing Process: Physical Attributes of Generic Tablets and Capsules
420
Bioequivalence in generic drugs, such as tablets and capsules, refers to their pharmaceutical equivalence to the brand-name counterparts. However, for therapeutic equivalence, manufacturers must also consider physical attributes like size, shape, and weight (FDA Guidance for Industry, December 2003). Discrepancies in these aspects could impact patient compliance and cause medication errors. For instance, swallowing difficulties, often experienced with larger tablets or capsules, can lead to...
420
01:24Design Example: Aggregate Gradation
470
The right type and quality of aggregates are crucial for concrete as they significantly influence its properties, mix proportions, and cost-effectiveness. If different sources are available for sand, the commonly used fine aggregate in concrete, the selection of sand is primarily based on its gradation.
The grading, or particle-size distribution, of sand is determined using sieve analysis, with standard sizes ranging from 150 μm to 10 mm (ASTM No. 100 sieve to 3⁄8 in. sieve). Sand is...
The grading, or particle-size distribution, of sand is determined using sieve analysis, with standard sizes ranging from 150 μm to 10 mm (ASTM No. 100 sieve to 3⁄8 in. sieve). Sand is...
470
01:28Methods of Medium Optimization
70
Optimizing growth media enhances microbial proliferation and maximizes product yield. Statistical experimental design methodologies provide structured and reproducible approaches, offering progressively higher levels of robustness and efficiency.The One-Factor-at-a-Time (OFAT) MethodThe One-Factor-at-a-Time (OFAT) method involves adjusting a single variable while keeping all others constant. However, it cannot detect interactions between variables, often leading to suboptimal outcomes when...
70