在接受关节骨折手术的老年患者中,辅助胺胺对抑郁症的影响:随机对照试验
Jiajing Cai1, Xiang Chen1, Ziyuan Jin1
1Department of Anesthesiology, Wenzhou People's Hospital, 57 CanHou street, Wenzhou, 325000, China.
BMC anesthesiology
|September 28, 2024
概括
在患者控制的静脉静脉止痛治疗 (PCIA) 中,辅助性胺显著减少了老年关节骨折患者的抑郁症. 这种治疗还增加了来自大脑的神经营养因子 (BDNF) 和5-西胺 (5-HT) 的水平.
科学领域:
- 麻醉学 麻醉学
- 老年精神病学是一门精神病学专业.
- 药理学 药理学是指药理学的学科.
背景情况:
- 抑郁症是老年患者部骨折手术后常见的并发症.
- 埃斯凯特胺显示出快速抗抑郁作用,但其在这种特定患者群体中的有效性尚未得到充分证实.
研究的目的:
- 调查骨骨折手术的老年患者在缓解抑郁症状时,作为患者控制的静脉静脉止痛 (PCIA) 的辅助剂,胺胺的有效性.
主要方法:
- 一项前性,双盲,随机对照试验,涉及90名患有部骨折的老年患者 (≥65岁).
- 患者接受了胺 (0.5毫克/千克) 或盐水作为PCIA辅助剂48小时.
- 抑郁症状的评估是使用老年抑郁量表-15 (GDS-15) 在术后的第2,7和30天进行的.
主要成果:
- 乙胺组的抑郁症患病率显著降低 (28.6%对53.5%),并在术后第二天的GDS-15分数显著降低.
- 乙胺组在术后第二天需要更少有效的PCIA压力.
- 在术后第二天,观察到脑衍生神经营养因子 (BDNF) 和5-西胺 (5-HT) 的血清度升高,在以斯基坦胺组.
结论:
- 在PCIA中,辅助的乙胺有效地改善了老年患者关节骨折手术后的抑郁症状.
- 素的使用与BDNF和5-HT水平的增加有关.
- 这项研究支持在这个易受伤害的患者群体中使用乙胺来治疗外科手术后抑郁症.
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