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免疫细胞组成及其对败血症儿童预后的影响
Huabin Wang1,2,3,4, Cheng Guo1,3,4, Yayan Wang1,3,4
1Department of Pediatrics, Affiliated Hospital of Jining Medical University, Jining Medical University, Jining, China.
BMC pediatrics
|September 28, 2024
概括
败血症儿童中中性粒细胞与淋巴细胞和血小板细胞 (NLPR) 的比率升高表明死亡风险较高. 这种简单的血液测试显示了与预测儿科败血症预后结果的既定得分相似的预后潜力.
科学领域:
- 儿科重症监护医药 儿科重症监护医药
- 免疫学 免疫学 免疫学
- 血液学 血液学 血液学
背景情况:
- 败血症的发病包括关键的免疫细胞反应.
- 评估免疫细胞比率为儿科败血症提供了预后见解.
研究的目的:
- 评估患有败血症的儿童中各种外周血液免疫细胞比率的预后意义.
- 确定这些比率对儿科败血症患者死亡率的预测值.
主要方法:
- 对230名败血症儿童的临床数据进行了回顾性分析.
- 计算中性粒细胞与淋巴细胞的比率 (NLR),衍生的NLR (dNLR),中性粒细胞与淋巴细胞和血小板的比率 (NLPR),单细胞与淋巴细胞的比率 (MLR) 和血小板与淋巴细胞的比率 (PLR).
- 使用LOWESS,ROC分析和K-M分析进行统计分析,以将比率与死亡率相关联.
主要成果:
- 所有测试的免疫细胞比率,除了PLR,在非幸存者中都更高.
- NLPR,NLR,MLR和dNLR显示与住院死亡率有线性关联.
- NLPR显示出最高的AUC (0.748),与儿科重症病评分 (PCIS) 相美.
- 增加的MLR,NLR,dNLR和NLPR与增加的30天死亡率有关.
结论:
- 这种NLPR是儿科败血症的潜在预后指标.
- NLPR的预测能力与已建立的PCIS相美.
- 免疫细胞比率为败血症儿童提供了有价值的预后信息.
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