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肺腺癌中的Hsa_circ_0079929及其对肺腺癌进展的生物学影响

Yuan Shen¹, Ruixue Han², Xin Yu³

¹Department of Internal Medicine, Huzhou Jiaotong Hospital, Huzhou, 313000, China.

Journal of cardiothoracic surgery

|September 28, 2024

概括

循环RNA hsa_circ_0079929 在肺腺癌中被上调,促进细胞增殖,迁移和入侵. 它的高表达与预后不佳相关,将其确定为潜在的治疗标.

科学领域:

在瘤学瘤学.
分子生物学分子生物学
遗传学遗传学是一个

背景情况:

肺腺癌是癌症死亡的主要原因之一.
循环RNAs (circRNAs) 越来越多地被认为是它们在癌症中的作用.
在肺腺癌中hsa_circ_0079929的特定作用仍然在很大程度上未被探索.

研究的目的:

为了研究hsa_circ_0079929在肺腺癌中的表达,预后价值和生物功能.
为了确定hsa_circ_0079929是否可以作为预后生物标志物.
阐明hsa_circ_0079929在肺腺癌进展中的作用背后的分子机制.

主要方法:

对肺腺癌组织和细胞系中的hsa_circ_0079929表达的分析.
对hsa_circ_0079929水平与临床参数和患者存活率的相关性分析 (奇平方,考克斯回归,卡普兰-梅尔).
在体外测试 (CCK-8,Transwell) 评估hsa_circ_0079929过度表达和对细胞增殖,迁移和入侵的影响.

主要成果:

与相邻的正常组织相比,肺腺癌组织中的Hsa_circ_0079929表达显著上调.
较高的hsa_circ_0079929水平与不良的临床特征和较差的整体存活率有关,将其确定为独立的预后因素.
过度表达hsa_circ_0079929促进了扩散,迁移和入侵,而它的淘汰抑制了这些恶性行为. Hsa_circ_0079929 作为 miR-1184.4 的分子诱.

结论:

Hsa_circ_0079929 在肺腺癌细胞中促进恶性表型.
Hsa_circ_0079929具有作为预后生物标志物和肺腺癌管理的治疗点的潜力.

关键词:

Hsa_circ_007992929 在线观看在线观看肺部腺癌瘤是肺部腺癌.预测预后预测预测一个进步的进步.

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