[血液恶性瘤和心血管风险增加:在患者随访中应考虑的新问题]
Vincenzo Toschi1, Maddalena Lettino2
1U.O. Medicina Interna, Casa di Cura Igea, Milano.
概括
血液癌症患者的长期存活率正在增加,但心血管并发症越来越令人担忧. 这些问题源于癌症本身,治疗方法和传统的风险因素.
科学领域:
- 血液学 血液学 血液学
- 心脏病学 心脏病学
- 在瘤学瘤学.
背景情况:
- 血液癌症治疗的显著改进导致了更多的长期幸存者.
- 增加的存活率与心血管并发症的增加并行,此前在这个人群中未被识别.
研究的目的:
- 为了突出血液癌症幸存者的新兴心血管风险.
- 为了阐明这些并发症的多因素原因.
主要方法:
- 对血液性恶性瘤的长期幸存者的临床结果和病因因素的审查.
- 对导致心血管疾病的癌症相关和治疗相关机制的分析.
主要成果:
- 血液癌症及其治疗诱导前血栓和前炎症状态.
- 抗瘤疗法增加了氧化应激,损害了细胞组件,如线粒体.
- 心血管并发症是由癌症,治疗和传统风险因素 (吸烟,高血压,肥胖,糖尿病) 之间的复杂相互作用造成的.
结论:
- 血液癌症幸存者面临心血管事件的风险增加,如心脏病发作,中风和静脉血栓栓塞.
- 临床医生必须将心血管风险评估纳入这些患者的后续护理.
- 适应的监测策略对于管理血液癌症的长期幸存者至关重要.
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