适用于患有的年轻人或生育潜力的处方模式
Elizabeth I Harrison1, Traci M Kazmerski2, Harry S Hochheiser3
1University of Pittsburgh Medical Center, 600 Grant Street, Pittsburgh, PA 15219, United States.
Epilepsy & behavior : E&B
|September 29, 2024
概括
患有生育期的年轻人 (YPWECP) 的叶酸和避孕率较低,增加了抗发作药物 (ASM) 的风险. 对这个脆弱群体需要改善生殖健康护理.
科学领域:
- 生殖健康 生殖健康
- 症管理 症管理
- 药物监督 药物监督 药物监督
背景情况:
- 患有生育可能期的年轻人 (YPWECP) 面临着来自性抗发作药物 (ASM) 的风险.
- ASM和避孕药之间的药物相互作用可能会导致突破性发作或避孕失败.
- 对于YPWECP来说,了解生殖健康保健的提供是至关重要的.
研究的目的:
- 分析YPWECP中叶酸和避孕药的处方模式.
- 调查相互作用的ASM和避孕药的联合处方.
- 在YPWECP中评估 TERATOGEN ASM启动期间的避孕措施覆盖率.
主要方法:
- 从2011-2021年对1525名YPWECP (年龄在13-21岁) 的处方数据的回顾性分析.
- 检查了叶酸处方,ASM与避孕药相互作用和拉莫特里金与避孕药相互作用的比率.
- 使用统计分析,包括逻辑回归和概括估计方程.
主要成果:
- 只有41%的YPWECP接受了叶酸;24%的人有相互作用的ASM-避孕药联合处方.
- 24%的拉莫特里金患者同时服用含有雌激素的药物,这些药物会影响血清水平.
- 只有13%的YPWECP在开始治疗原性ASM之前已经记录了避孕措施.
- 年龄较高与 TERATOGEN ASM 发病前更好的避孕措施覆盖率相关.
结论:
- YPWECP表现出低叶酸和避孕药处方率,增加了风险.
- 药物相互作用和避孕失败对YPWECP构成重大风险.
- 为了YPWECP,需要加强生殖保健干预措施.
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