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双动电化学带由可编程多式联机可穿戴电位器操作

Ibrahim Bozyel¹, Derek Fleming², Kim Won-Jun³

¹The Gene and Linda Voiland School of Chemical Engineering and Bioengineering, Washington State University, Pullman, WA, USA; Department of Electrical and Computer Engineering, Worcester Polytechnic Institute, Worcester, MA, USA.

Biosensors & bioelectronics

|September 29, 2024

概括

一种新的可编程电化学带 (e-bandage) 可以产生低酸 (HOCl) 或过氧化 (H2O2) 来对抗生物膜感染. 这种双重作用的电子带在体外有效杀死细菌和真菌,并促进小鼠的伤口愈合.

科学领域:

生物医学工程生物医学工程
材料科学材料科学材料科学
传染性疾病传染性疾病

背景情况:

生物膜感染的伤口由于微生物耐药性而构成重大临床挑战.
产生反应性氧物种 (ROS) 的电化学带 (e-bandage),如HOCl和H2O2,对治疗这些感染有很大的希望.
之前的研究表明HOCl和H2O2的功效差异,而H2O2在体内表现出更好的伤口愈合.

研究的目的:

开发一个可编程的多式联机可穿戴电位器 (PMWP) 来自电子带按需生成HOCl和H2O2.
评估交替生成的HOCl和H2O2对临床相关病原体小组的双重作用能力.
在小鼠伤口感染模型中评估PMWP控制的电子带系统的性能和可用性.

主要方法:

用于PMWP操作的超低功率微控制器单元的开发,由硬币电池供电.
PMWP的电化学表征,以确保与商业电位器可比的性能.
在实验室中测试PMWP控制的电子带,对抗抗甲素耐药黄金葡萄球菌,Pseudomonas aeruginosa,Acinetobacter baumannii,Enterococcus faecium和Candida auris的生物膜.
在动物体内评估PMWP在小鼠伤口感染模型中的可用性.

主要成果:

重量为4.6g,由260mAh电池供电的PMWP系统表现出与台式电源控制器可比的电化学性能.
经PMWP控制的电子带被编程为顺序输送HOCl和H2O2,在所有测试的临床分离物的生物膜上表现出强烈的体外活性.
该系统的可用性在小鼠伤口感染模型中成功证明,突出了其进一步开发的潜力.

结论:

开发的PMWP可实现可编程的,双重作用的ROS生成用于电子带,提供了一种对抗生物膜感染的多功能方法.
由PMWP控制的电子带交替输送HOCl和H2O2,显示了针对具有挑战性的病原体的广泛抗菌活性.
这项技术具有很大的潜力,可以促进慢性和感染性伤口的治疗,并将在未来用于人类临床试验.

关键词:

生物膜是一种生物膜.电化学带的使用方法小鼠伤口感染模型.可穿戴的电源控制器.伤口愈合伤口愈合

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