混合暴露于微塑料与精子功能障碍的关联:一项在中国的多地点研究
Chen Zhang1, Guanghui Zhang2, Kuan Sun3
1Institute of Reproduction and Development, Obstetrics and Gynecology Hospital of Fudan University, Shanghai 200032, China.
EBioMedicine
|September 29, 2024
概括
在男性生殖样本中发现了微塑料,包括来自不粘的PTFE,这些微塑料与精子质量降低有关. 尿液检测可能表明男性生殖性微塑料暴露,突出潜在的生育风险.
科学领域:
- 环境科学 环境科学
- 生殖生物学 生殖生物学
- 毒理学 毒理学 毒理学
背景情况:
- 微塑料是人类组织中普遍存在的环境污染物,具有潜在的健康风险.
- 微塑料对男性生殖系统的存在和影响在很大程度上仍未得到研究.
- 这项研究通过检查精液和尿液中的微塑料及其对精子质量的影响来解决知识差距.
研究的目的:
- 在人类精液和尿液样本中调查八种类型的微塑料的存在.
- 评估微塑料暴露与男性精液质量关键参数之间的关联.
- 探索尿液测试作为男性生殖性微塑性暴露的生物标志物的实用性.
主要方法:
- 一项涉及中国三个地区113名男性参与者的横截面研究.
- 拉曼显微镜用于检测精液和尿液中的微塑料 (PS,PP,PC,PE,PVC,PTFE,PET,ABS).
- 分析了精液质量参数 (数量,度,运动性,形态),统计模型根据混因素进行调整.
主要成果:
- 在所有样本中检测到微塑料,参与者平均接触到3-5种类型.
- 聚钢 (PS),聚烯 (PP) 和聚乙烯 (PE) 的检测率最高.
- 暴露于聚四乙烯 (PTFE) 与精子数量,度和运动率的减少显著相关.
结论:
- 微塑料污染给男性带来潜在的生殖健康风险,而PTFE是一个值得关注的问题.
- 尿液微塑料分析显示,它是男性生殖暴露的指标.
- 需要进一步的研究,以了解微塑料对男性生育能力的影响机制和潜在的跨代影响.
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