患有多发性硬化症的妇女的抑郁和久坐行为
Eduarda F A Machado1, Felipe V Glehn2, Jeffer Sasaki3
1Universidade de Brasília, Faculdade de Educação Física, Laboratório de Análise do Movimento Humano, Brasília, Distrito Federal CEP: 70910-900, Brazil; Centro Universitário Euro-Americano, Faculdade de Medicina, Brasília, Distrito Federal, Brazil; Universidade de Rio Verde, Faculdade de Medicina, Formosa, Goiás, Brazil.
Multiple sclerosis and related disorders
|September 29, 2024
概括
患有多发性硬化症 (MS) 的女性的抑郁症与增加的久坐行为有关,即使身体活动水平相似. 解决抑郁症和长时间坐着是MS管理和预防其他健康问题的关键.
科学领域:
- 神经学 神经学
- 精神病学是一个精神病学.
- 公共卫生 公共卫生
背景情况:
- 抑郁症在多发性硬化症 (MS) 中很普遍,影响约50%的个体.
- 与普通人群相比,患有多发性硬化症 (pwMS) 的人表现出身体活动减少和久坐行为增加.
- 了解抑郁症与 pwMS 中的久坐行为之间的联系对于有效的治疗策略至关重要.
研究的目的:
- 研究患有复发性复发性多发性硬化症 (RRMS) 的女性抑郁症状和久坐行为持续时间之间的关联.
- 评估MS和没有MS的女性抑郁症,久坐,身体活动和疲劳之间的关系.
主要方法:
- 一项涉及78名女性的横截面研究:38名RRMS (EDSS 1-3) 和40名健康对照.
- 在三个组中评估抑郁症,久坐时间,身体活动水平和主观疲劳:对照组 (CG),患有抑郁症的MS (MSD) 和没有抑郁症的MS (MSND).
- 使用后勤回归分析来确定与MS患者抑郁症相关的因素.
主要成果:
- 与没有抑郁症 (MSND) 的MS患者相比,患有MS和抑郁症 (MSD) 的女性表现出明显更长的久坐行为持续时间.
- 抑郁症被确定为与MS患者的久坐行为相关的重要因素 (OR=1.62,p=0.021),即使在多变量调整后也是如此.
- 在MSD和MSND组之间没有发现临床残疾 (EDSS) 或体力活动水平的显著差异,这表明这种关联独立于体力活动.
结论:
- 在患有复发性复发性多发性硬化症的妇女中,抑郁症和长时间的久坐行为之间存在显著的关系,独立于身体活动水平.
- 在pwMS中增加的久坐不动行为是心血管疾病等并发症的危险因素,强调需要对抑郁症和久坐不动行为的综合管理.
- 进一步国际研究不同 pwMS 群体的久坐行为对于开发文化定制干预措施至关重要.
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