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Updated: Jun 11, 2025

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TERRA长非编码RNA:在端粒损伤的介面阶段,救援和信号传递

Eftychia Kyriacou¹, Joachim Lingner¹

¹Swiss Institute for Experimental Cancer Research (ISREC), School of Life Sciences, École Polytechnique Fédérale de Lausanne (EPFL), 1015 Lausanne, Switzerland.

Current opinion in cell biology

|September 29, 2024

概括

长非编码RNA对于端粒维护和DNA修复至关重要. 这些RNAs影响癌细胞生存,衰老和细胞死亡途径.

科学领域:

分子生物学分子生物学
遗传学遗传学是一个
细胞生物学细胞生物学

背景情况:

长非编码RNAs (lncRNAs) 是端粒生物学的一个组成部分.
它们通过诸如端粒酶和同质导向修复 (HDR) 等机制来调节端粒维护.
TERRA lncRNAs参与了端粒DNA损伤反应.

研究的目的:

阐明TERRA lncRNAs在端粒功能中的多方面的作用.
了解TERRA在DNA修复途径和细胞过程中的参与.
探索TERRA在衰老,癌症和细胞死亡中的重要性.

主要方法:

研究TERRA与端粒DNA和相关蛋白质的相互作用.
分析TERRA对DNA复制和修复途径的影响.
研究TERRA在细胞衰老和自细胞死亡中的功能.

主要成果:

TERRA lncRNAs通过R循环形成与端粒结合,其中包括RAD51和RAD51AP1.
由TERRA调解的端粒R环促进了向HDR转变,以维护端粒.
这种HDR通路对于癌细胞中的端粒替代延长 (ALT) 是必不可少的.
此外,TERRA还可以刺激衰老细胞中的HDR,延迟衰老,并在危机期间调解癌细胞的自细胞死亡.

结论:

TERRA lncRNAs是端粒维护和基因组稳定性的关键调节者.
TERRA在癌症中起着双重作用,促进ALT细胞中的端粒维护,并在其他细胞中诱导细胞死亡.
TERRA的功能延伸到细胞衰老和DNA损伤反应,突出其广泛的生物意义.

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