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Updated: Aug 1, 2026

Predicting In Vivo Payloads Delivery using a Blood-brain Tumor-barrier in a Dish
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天体细胞衍生的细胞外囊泡在减轻人脑内皮细胞中细胞毒性和转录组变化的治疗潜力

Ruth Stewart1, K Hope Hutson1, Gergana G Nestorova1

  • 1School of Biological Sciences, Louisiana Tech University, Ruston, LA, 71270, USA.

Neuroscience
|September 29, 2024
PubMed
概括

星细胞衍生的细胞外囊泡 (EVs) 通过降低人类大脑内皮细胞 (HBECs) 中的神经毒性来显示治疗潜力. 这些EV减轻了氧化DNA损伤和细胞毒性,为神经退行性疾病治疗提供了前景.

关键词:
8OHdG是什么意思 8OHdG是什么意思血液-大脑屏障是什么?细胞外囊泡中的细胞外囊泡.神经退行发生神经退行.在cnRNA中.

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The ability of induced pluripotent stem cells or iPSCs to differentiate into most body cell types has stimulated repair and regenerative medicine research over the past few decades. iPSC-derived blood cells, hepatocytes, beta islet cells, cardiomyocytes, neurons, and other cell types can repair injuries or regenerate damaged tissue in diseases such as diabetes and neurodegenerative disorders.
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Forced Transdifferentiation

Transdifferentiation, also known as lineage reprogramming, was first discovered by Selman and Kafatos in 1974 in silkmoths. They observed that the moths’ cuticle-producing cells transformed into salt-producing cells. Many such cases of natural transdifferentiation occur in organisms. In humans, pancreatic alpha cells can become beta cells. In newts, the loss of the eye’s lens causes the pigmented epithelial cells to transdifferentiate into the lens cells.
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Methods of Nuclear Reprogramming

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