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在分娩后的奶牛中,亚临床症和仓库随着脂肪组织氧利平因特征的变化

Bridger B Sparks¹, Hunter Ford¹, Tainara C Michelotti¹

¹Department of Veterinary Sciences, Davis College of Agricultural Sciences and Natural Resources, Texas Tech University, Lubbock, TX 79409.

Journal of dairy science

|September 29, 2024

概括

产后奶牛在皮下和内脏储存之间表现出明显的脂肪组织氧利平蛋白配置,受到亚临床症的影响. 这些 oxylipins 影响脂肪细胞功能,突出显示它们在代谢健康中的作用.

科学领域:

牲畜中的新陈代谢障碍
脂质新陈代谢和信号传递
脂肪组织生物学脂肪组织生物学

背景情况:

脂解在周周的奶牛中是自然的,但如果过度,可能导致症等疾病.
多不和脂肪酸 (PUFA) 的氧化产生氧利平,它调节炎症和新陈代谢.
了解仓库特定的氧利平蛋白概况对于管理奶牛健康至关重要.

研究的目的:

为了识别乳牛脂肪组织氧利平因型的仓库特异性差异,具有和没有亚临床症.
评估特定氧利平在体外对脂肪细胞功能的影响.

主要方法:

采集了非基因素 (NK) 和亚临床基因素 (SCK) 乳牛的皮下脂肪组织 (SAT) 和内脏脂肪组织 (VAT).
进行向性脂组学检测 154 种氧利平在配对的 SAT 和 VAT 样本中.
在实验室中研究了精选的氧利平 (TXB2,PGA2,5-HETE) 对SAT和VAT脂肪细胞功能的影响.

主要成果:

在两个脂肪组织储存库中确定了50个氧利平;SCK与TXB2降低和PGA2和PGE1增加有关.
在SCK奶牛中,SAT显示了PGE1,15-keto-PGE2,13,14-dihydro-15-keto-PGE2,5-HETE和15-HETE的水平增加.
增值税表现出较高的特定氧和氧八十三烯酸的丰度;体外,5-HETE增加了增值税细胞的增殖,TXB2降低了SAT脂质积累,PGA2降低了增值税细胞ROS.

结论:

产后奶牛具有特定于仓库的脂肪组织脂质学特征,这些特征与症状态有关.
氧利平在调节脂肪细胞功能,增殖,脂质积累和反应性氧物种 (ROS) 生产方面发挥作用.
这些发现有助于了解乳牛中亚临床症相关的代谢障碍.

关键词:

脂肪组织的脂肪组织.症是指症 (ketosis) 的一种情况.氧利平素是一种氧利平素.过渡时期的牛过渡期的牛

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