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Doxycycline Loaded Collagen-Chitosan Composite Scaffold for the Accelerated Healing of Diabetic Wounds

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开发一种多功能酸盐复合海绵,用于治疗创伤性伤害.

Zhicheng Liu¹, Hao Zhang², Huining Su¹

¹School of Chemistry, Xi'an Key Laboratory of Sustainable Energy Material Chemistry, Xi'an Jiaotong University, Xi'an 710049, PR China.

International journal of biological macromolecules

|September 29, 2024

概括

此摘要是机器生成的。

一个新的基托桑,纤维素,石墨烯氧化物和银纳米复合物海绵提供了卓越的血液静止. 这种先进的材料有效降低出血和感染风险,显示创伤护理应用的希望.

关键词:

抗菌是一种抗菌剂.纤维素纤维素是一种纤维素.基托桑是一种酸盐.石墨烯氧化物石墨烯氧化物静血海绵是一种静血海绵.失控的出血失控的出血

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科学领域:

生物材料科学生物材料科学
纳米技术纳米技术
材料化学材料化学

背景情况:

开发有效的止血剂对于控制出血至关重要,因为传统方法存在诸如感染风险和低于最佳的疗效等局限性.
目前的静血技术经常与严重出血病例作斗争,需要创新的解决方案.

研究的目的:

推出一种新的多功能纳米复合体海绵,用于增强血静.
评估开发的海绵的静血,生物相容性和抗菌性质.

主要方法:

一种纳米复合体海绵的制造,其中包含素 (CS),纤维素 (Cel),石墨烯氧化物 (GO) 和银 (Ag) 纳米粒子.
评估物理性能,包括膨胀率,吸收率和机械强度.
在体外评估细胞相容性,血液溶解,血细胞粘附性和抗菌活性.
在老鼠模型中进行体内测试 (尾巴截肢,肝损伤,大腿动脉破裂) 以评估静血疗效.

主要成果:

CS/Cel/GO/Ag海绵表现出高胀率 (>3000%) 和吸收率 (>2100%) 与显著的机械强度 (>20 kPa).
试验室研究证实了良好的细胞兼容性,非溶血性质,有效的血细胞粘附性和强大的细菌抑制.
在体内测试表明,在多种损伤模型中,血液静止得到了实质性的改善,与传统方法相比,大大减少了凝血时间和血液损失.

结论:

CS/Cel/GO/Ag纳米复合体海绵为急性出血管理提供了一个有前途的多功能材料.
它的优越的静血性能,生物相容性和抗菌性质表明它在创伤护理中具有显著的潜力.