风湿性关节炎患者的潜在队列中的气道异常
Scott M Matson1, Jiwoong Choi1, Drayton Rorah2
1Department of Pulmonary, Critical Care and Sleep Medicine, University of Kansas Medical Cente, Kansas City, KS.
Chest
|September 29, 2024
概括
空气疾病在类风湿性关节炎 (RA) 患者中很常见,往往诊断不足. 定量CT成像显示了与呼吸道症状相关的严重气道异常,这表明它是一种未被认可的RA表现.
科学领域:
- 肺部医学 肺部医学
- 类风湿病学 类风湿病学
- 放射学 放射学是一门学科.
- 医疗成像医学成像
背景情况:
- 类风湿性关节炎 (RA) 影响大约1%的人口,经常涉及肺部.
- 虽然在RA中承认间歇性肺病 (ILD),但呼吸道疾病仍未得到充分研究.
- 这项研究调查了没有被诊断为ILD的RA患者的空气道基线异常.
研究的目的:
- 为了评估潜在的类风湿性关节炎 (RA) 队列的基线呼吸道异常.
- 为了将这些异常与肺功能测试 (PFT) 和高分辨率CT (HRCT) 发现相关联.
- 探索RA患者的呼吸道疾病和呼吸道症状之间的关联.
主要方法:
- 188名没有ILD的RA患者接受了HRCT成像和PFT.
- 放射科医生评估了HRCT扫描的气道异常.
- 计算成像 (VIDA Vision) 和定量CT分析被用来量化147名患者的呼吸道异常.
主要成果:
- 在20.7%的患者中发现了气道阻塞 (FEV1/FVC < 0.7),与年龄较大,男性性别和吸烟有关.
- 放射科医生在61%的患者中检测到气道异常,包括支气管壁加厚 (55%) 和支气管切除症 (12%).
- 定量CT指标与PFT阻塞和更严重的呼吸道症状 (如呼吸短促和咳) 相相关.
结论:
- 在这种RA队列中,使用多种方法检测到高比例的气道异常.
- 定量CT测量显示,与呼吸道症状有显著的关联.
- 空气疾病可能是RA的未被认可的外关节表现,可通过定量CT成像检测到.
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