美国军方退伍军人重度抗治疗抑郁症的单剂量psilocybin - - 一项首次的开放标签试点研究
Sara Ellis1, Catherine Bostian2, Wendy Feng1
1VA Palo Alto Health Care System, Palo Alto, CA, USA; Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Palo Alto, CA, USA.
Journal of affective disorders
|September 29, 2024
概括
在退伍军人的严重抑郁症中,psilocybin显示出有前途. 这项初步研究发现,在治疗耐药性抑郁症 (TRD) 的退伍军人中,显著的反应和缓解率被发现,这表明了潜在的新治疗途径.
科学领域:
- 精神病学是一个精神病学.
- 神经科学是一个神经科学.
- 药理学 药理学是指药理学的学科.
背景情况:
- 严重的抑郁严重影响退伍军人,导致高自杀率和残疾率.
- 退伍军人治疗耐药性抑郁症 (TRD) 是一种严重的未满足的医疗需求.
- 这项研究是首次调查psilocybin在这个人群中的有效性和安全性.
研究的目的:
- 评估psilocybin在退伍军人中治疗耐药性严重抑郁症 (TRD) 的疗效和安全性.
- 用蒙哥马利-阿斯伯格抑郁症评分表 (MADRS) 来评估抑郁症症状的减少.
- 探索迷幻体验和治疗反应之间的关系.
主要方法:
- 十五名患有严重TRD的退伍军人接受了单次25毫克的psilocybin.
- 参与者接受治疗前逐渐减少抗抑郁药的治疗.
- 抑郁症结局 (反应和缓解) 被测量在治疗后3周和12周.
- 通过不良事件和自杀评估来监测安全性.
主要成果:
- 在3周后,60%的参与者达到反应标准,53%的参与者实现了缓解.
- 在12周后,47%的患者维持了反应,40%的患者维持了缓解.
- 心理学体验的强度和抑郁症结果之间没有发现显著的相关性.
- 在研究期间没有报告任何意外不良事件.
结论:
- 在重度TRD的退伍军人中,psilocybin表现出显著的反应和缓解率.
- 并发性创伤后应激障碍 (PTSD) 似乎没有缓解治疗结果.
- 需要进一步的研究,以在更大的受控试验中证实这些发现.
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