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认知障碍的差异及其与循环无细胞线粒体DNA的相关性在无药抑郁症和双极抑郁症患者中

Kun Jin¹, Ziwei Teng², Jiaxin Li¹

¹Department of Psychiatry, National Clinical Research Center for Mental Disorders and National Center for Mental Disorders, The Second Xiangya Hospital of Central South University, Changsha 410011, Hunan, China.

Journal of affective disorders

|September 29, 2024

概括

与健康对照组相比,双极性抑郁症 (BD) 和严重抑郁症 (MDD) 的没有药物治疗的患者表现出认知障碍. 循环无细胞线粒体DNA (ccf-mtDNA) 水平的增加与抑郁症的严重程度有关,可能在BD和MDD中发挥作用.

科学领域:

神经科学是一个神经科学.
精神病学是一个精神病学.
遗传学遗传学是一个

背景情况:

认知障碍是主要抑郁症 (MDD) 和双极性抑郁症 (BD) 的核心特征.
循环无细胞线粒体DNA (ccf-mtDNA) 已成为各种疾病的潜在生物标志物,包括精神疾病.
了解特定的认知缺陷及其与ccf-mtDNA等生物标志物的关系对于推进治疗策略至关重要.

研究的目的:

为了比较BD和MDD的无药患者之间的认知功能.
研究这些患者群体中循环无细胞mtDNA (ccf-mtDNA) 水平与认知障碍之间的关联.
探索ccf-mtDNA在BD和MDD病理生理学的作用.

主要方法:

横截面研究包括76名BD患者,86名MDD患者和70名健康对照 (HC).
使用可重复电池用于评估神经心理状态 (RBANS) 和Stroop Color-Word测试来评估认知功能.
使用定量聚合酶链反应 (qPCR) 量化血ccf-mtDNA水平.

主要成果:

与HC相比,BD和MDD患者在即时记忆,语言,注意力和延迟记忆方面的得分明显较低.
BD患者的视觉空间/构造性得分明显低于HC和MDD患者.
与HC相比,BD和MDD组的ccf-mtDNA水平都较高,在MDD组观察到的水平更高. ccf-mtDNA与抑郁症患者的语言功能有负相关性.

结论:

在BD和MDD患者之间存在不同的认知特征,特别是在视觉空间功能方面.
在BD和MDD中CCF-mtDNA水平升高表明它参与了这些疾病的潜在病理生理学.
ccf-mtDNA可以作为潜在的生物标志物用于认知障碍和抑郁症中的疾病活性.

关键词:

双极性抑郁症是一种双极性抑郁症.循环的无细胞线粒体DNA.认知障碍认知障碍是一种认知障碍.大型抑郁症主要是抑郁症.

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