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纸板一次性间隔器与用于喷雾剂输送的商业门持有室的比较性能研究

Emma Eynaud¹, Lara Leclerc¹, Manon Moreau-Neidhardt¹

¹Mines Saint-Etienne, Univ Jean Monnet, INSERM, U 1059 Sainbiose, Centre CIS, F - 42023 Saint-Etienne France.

International journal of pharmaceutics

|September 29, 2024

概括

廉价的纸板间隔器有效地传递流他 propionate 气溶,与商业设备相似. 这些低技术的选择提供了类似的可呼吸分数,确保了压力计量剂量吸入器 (pMDI) 使用的最佳治疗效果.

科学领域:

呼吸系统药物呼吸系统药物
制药技术制药技术制药技术
医疗器械工程医疗器械工程

背景情况:

压力计量剂量吸入器 (pMDIs) 需要有效的输送设备来实现最佳的药物沉积.
式保持室 (VHC) 和间隔器提高了pMDI的性能,但成本和复杂性各不相同.
需要低技术,廉价的气溶输送替代品.

研究的目的:

评估和比较两种低技术纸板间隔器与两种商业式保持室 (VHC) 的性能,以通过pMDI给药酸.
为了评估总排放剂量 (TED) 和空气动力学颗粒大小分布.

主要方法:

根据加拿大标准CAN/CSA-Z264.1-02的pMDI测试了四种设备:一个自制的纸杯间隔器,一个DispozABLE®纸板间隔器,一个AeroChamber Plus®塑料VHC和一个Vortex®VHC.
测量包括总发射剂量 (TED) 和空气动力学颗粒大小分布.

主要成果:

与商用塑料VHC.相比,纸板间隔器提供了超过2.5倍的流动剂量.
三种抗静电装置 (VHC,可放式®间距器,纸杯间距器) 提供了明显高于塑料VHC的细颗粒剂量.
来自抗静电装置的细颗粒分数与没有间隔器的pMDI相似,确保了最佳的治疗效果.
所有测试的间隔器都减少了粗颗粒的传递,最大限度地减少了口腔喉沉积.

结论:

廉价,低技术的纸板间隔器是使用pMDIs进行气溶输送的可行替代品.
这些设备提供与更复杂的商业选项相比较的细颗粒传递.
纸板间隔器有助于有效的化 propionate 管理,可能改善患者的治疗结果.

关键词:

气溶的交付方式气溶颗粒的颗粒大小是什么有成本效益的成本效益.弗鲁塔西松是一种流动.这是低技术的低技术.间隔器 Spacer 间隔器是一个空间器.门式持有室门式持有室在 pMDI 的情况下,pMDI 是 pMDI.

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