温度和动脉内心介质厚度:年轻成年人冠状动脉风险发展研究 (CARDIA)
Brian T Joyce1, Jie Yao2, Yinan Zheng1
1Department of Preventive Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.
The Science of the total environment
|September 29, 2024
概括
长期的环境温度,特别是冬季的温度变化,与早期心血管疾病标志物,如动脉内心介质厚度 (cIMT) 有关. 最低的夏季温度也显示了相关性,突出了地理位置.
科学领域:
- 环境健康 环境健康
- 心血管流行病学心血管流行病学
- 动脉样硬化研究 动脉样硬化研究
背景情况:
- 关于环境温度对早期心血管疾病 (CVD) 指标的长期影响的研究有限.
- Carotid intima-media 厚度 (cIMT) 是亚临床动脉样硬化的一个关键指标.
研究的目的:
- 调查长期环境温度指标与cIMT之间的关联.
- 通过种族和性别来探索这些协会的潜在差异.
主要方法:
- 利用了来自3257名参与者在年轻成年人冠状动脉风险发展研究 (CARDIA) 的数据.
- 通过使用北美土地数据同化系统数据,获得了12个环境温度指标 (夏季,冬季,全年平均值,最小值,最大值,SD).
- 检查了与cIMT的横截面和潜在关联,并按种族和性别进行了分层分析.
主要成果:
- 冬季温度标准偏差与降低cIMT相关 (β = -0.0104 mm/°C).
- 最低的夏季温度与cIMT的增加有关 (β = 0.0020 mm/°C).
- 女性比男性更强烈的关联;没有观察到种族的实质差异. 累积温度与cIMT没有关联.
结论:
- 环境温度,特别是冬季的温度变化,可能在亚临床动脉样硬化 (cIMT) 的发展中发挥作用.
- 研究结果表明,与气候变化相关的公共卫生战略可能会产生潜在影响.
- 需要进一步的研究来证实这些关联,并解决混因素.
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