在台湾两家公共精神病院出院的老年双相情感障碍患者的处方模式,2006-2019年
Ching-Hua Lin1,2,3, Ching-Chi Hsu4,5, Hung-Yu Chan6,7
1Kaohsiung Municipal Kai-Syuan Psychiatric Hospital, Kaohsiung, Taiwan.
概括
老年双相情感障碍 (OABD) 的药理治疗发生了显著的转变. 第二代抗精神病药和抗抑郁药的处方增加,而等情绪稳定剂的处方减少,与治疗指南相悖.
科学领域:
- 老年精神病学是一门精神病学专业.
- 药理学 药理学是指药理学的学科.
- 双极性障碍研究研究
背景情况:
- 老年双相情感障碍 (OABD) 影响60岁及以上的个人.
- 关于OABD药物治疗的时间趋势的研究有限.
- 本研究考察了台湾在2006-2019年间的OABD处方变化.
研究的目的:
- 调查老年双相情感障碍的药理治疗中的时间趋势.
- 分析心情稳定剂,抗精神病药物和抗抑郁药物处方的变化.
- 为了识别OABD患者的多药模式的变化.
主要方法:
- 对1072名OABD患者的分析,这些患者从台湾两家公共精神病院 (2006-2019) 出院.
- 检查了处方的情绪稳定剂 (,瓦尔酸盐,卡巴马西平,拉莫特里金),抗精神病药物 (SGA,FGA) 和抗抑郁药.
- 复杂的多药学定义为使用三种或更多的药物;使用Cochran-Armitage趋势测试分析趋势.
主要成果:
- 第二代抗精神病药物 (SGA) 是最常见的 (72.0%),其次是氨酸 (48.4%) 和抗抑郁药 (21.7%).
- 观察到SGA,抗抑郁药,不含情绪稳定剂的抗抑郁药和复杂多药物的显著增加.
- 情绪稳定剂,,第一代抗精神病药物 (FGA) 和抗抑郁药以及情绪稳定剂的显著下降.
结论:
- 在14年内,OABD患者的处方模式发生了重大变化.
- 减少和增加抗抑郁药的使用偏离了既定的双相治疗指南.
- 需要进一步的研究来评估这些处方转换的临床结果.
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