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胰岛素样生长因子II mRNA结合蛋白3在中枢神经系统的原发性扩散性大B细胞淋巴瘤中高度表达

Kentaro Odani¹, Masakazu Fujimoto², Hirotake Fujii¹

¹Department of Diagnostic Pathology, Osaka Red Cross Hospital, Osaka, Japan.

Journal of clinical and experimental hematopathology : JCEH

|September 29, 2024

概括

胰岛素样生长因子II mRNA结合蛋白3 (IMP3) 免疫组织化学在中枢神经系统扩散型大B细胞淋巴瘤 (CNS-DLBCL) 中表达高. IMP3可能有助于诊断中枢神经系统-DLBCL,特别是当瘤细胞稀缺时.

科学领域:

神经病理学神经病理学
在瘤学瘤学.
免疫组织化学免疫组织化学

背景情况:

主要的中枢神经系统扩散性大B细胞淋巴瘤 (CNS-DLBCL) 诊断是具有挑战性的,因为有限的活检组织.
准确的诊断对于有效治疗中枢神经系统-DLBCL至关重要.

研究的目的:

评估胰岛素样生长因子II mRNA结合蛋白3 (IMP3) 免疫组织化学 (IHC) 作为中枢神经系统DLBCL的辅助诊断标记物的实用性.
评估与其他DLBCL亚型和炎症性脑疾病相比,中枢神经系统DLBCL中的IMP3表达.

主要方法:

在57个中枢神经系统-DLBCL活检样本,68个非中枢神经系统-DLBCL样本和12个炎症性脑疾病样本上进行了IMP3免疫组织化学 (IHC).
细胞质IMP3表达被量化为阳性瘤细胞的百分比.

主要成果:

百分之百的中枢神经系统-DLBCL病例 (57/57) 在≥50%的瘤细胞中显示出细胞质IMP3表达.
在88.2% (60/68) 的非CNS-DLBCL中观察到IMP3表达.
在炎症性脑疾病中没有发现IMP3阳性B细胞 (P < 0.0001).

结论:

在中枢神经系统DLBCL中IMP3的表达很高,但在其他DLBCL类型中也很高,这表明特异性有限.
IMP3 IHC可以是一个有价值的辅助工具,用于区分中枢神经系统DLBCL和反应性病变,特别是当瘤细胞稀疏或变形时.

关键词:

免疫组织化学免疫组织化学类似胰岛素的增长因子II mRNA结合蛋白3 中枢神经系统的原发性扩散大B细胞淋巴瘤.

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