在使用塞马格卢提德时,对禁食患者的胃含量进行评估:一项观察性研究
Veronica Neves Fialho Queiroz1, Priscila Mina Falsarella2, Renato Carneiro de Freitas Chaves3
1Department of Anesthesiology, Hospital Israelita Albert Einstein, São Paulo, São Paulo, Brazil.
概括
塞马格卢提德的使用显著增加了饥饿后胃充满的可能性,以及胃肠道症状,如恶心和食欲丧失.
科学领域:
- 胃肠病学 胃肠病学
- 药理学 药理学是指药理学的学科.
- 医疗成像医学成像
背景情况:
- 众所周知,类似葡萄糖-1 (GLP-1) 激动剂,如塞马格卢提德,会影响胃空气.
- 这种影响引发了辩论,特别是关于遵守禁食协议的问题.
研究的目的:
- 为了研究塞马格卢提德对胃内容的影响.
- 在志愿者研究中使用超声波评估胃排空.
主要方法:
- 观察性,横截面,单中心研究.
- 30名成年志愿者在过夜禁食后接受了胃超声波.
- 15名志愿者接受了塞马格卢提德 (在7天内);15人是对照组.
主要成果:
- 塞马格卢提德的使用者显示,胃充满的患病率明显更高 (73%与7%相比).
- 在塞马格卢提德组中观察到胃肠道症状增加:早期腹感 (67%),食欲丧失 (67%),胃充满 (53%) 和恶心 (47%).
- 塞马格卢提德组的任何参与者在禁食后都没有空腹.
结论:
- 塞马格卢提德的使用与延迟胃空虚有关,即使在适当的禁食后,胃也会满.
- 塞马格卢提德与胃肠道副作用的发病率较高有关,包括早期腹感,食欲丧失,胃腹和恶心.
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