三种客观营养查工具的比较,用于识别胃癌患者GLIM定义的营养不良
Junbo Zuo1,2, Yan Huang2,3, Zhenhua Huang1
1Department of General Surgery, The Affiliated People's Hospital of Jiangsu University, Zhenjiang, China.
老年营养风险指数 (GNRI) 是识别胃癌患者营养不良的最有效工具,其表现优于预后营养指数 (PNI) 和控制营养状况 (CONUT) 评分. 这一发现有助于对胃癌患者进行更好的营养评估.
科学领域:
- 在瘤学瘤学.
- 营养科学 营养科学
- 医学诊断 医学诊断 医学诊断
背景情况:
- 胃癌 (GC) 患者经常出现营养不良,影响治疗结果.
- 客观的营养查工具对于早期发现和管理营养不良至关重要.
研究的目的:
- 为了比较三个客观的营养查工具的有效性:老年营养风险指数 (GNRI),预后营养指数 (PNI) 和控制营养状况 (CONUT) 评分.
- 确定用于检测胃癌患者的全球营养不良领导倡议 (GLIM) 定义的营养不良的最佳工具.
主要方法:
- 在316名胃癌患者中评估了GNRI,PNI和CONUT得分.
- 使用GLIM标准诊断的营养不良.
- 通过接收器操作特征 (ROC) 曲线评估诊断值,计算曲线下的面积 (AUC),灵敏度,特异性,准确性,正预测值 (PPV) 和负预测值 (NPV).
- 使用卡帕系数 (k) 确定协议.
主要成果:
- 根据GLIM标准,47.8%的患者被诊断出营养不良.
- 在GLIM定义的营养不良方面,GNRI显示了高的诊断准确性 (AUC=0.805).
- PNI (AUC=0.699) 和CONUT (AUC=0.665) 的诊断准确性较低.
- GNRI表现出最高的特异性 (80.0%),准确性 (72.8%),PPV (74.8%),NPV (71.4%),以及一致性 (k=0.452).
结论:
- 与PNI和CONUT相比,GNRI是一种卓越的客观营养查工具,用于识别胃癌患者的GLIM定义的营养不良.
- 这些发现支持使用GNRI来改善这种患者群体的营养评估和管理.
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