在极度早产婴儿中,产后体重减轻和神经发育结果在3岁时:一项队列研究
Kei Tamai1, Naomi Matsumoto2, Takashi Yorifuji2
1Division of Neonatology, NHO Okayama Medical Center, 1711-1 Tamasu, Kita-ku, Okayama, 701-1192, Japan. gmd501041@s.okayama-u.ac.jp.
BMC pediatrics
|September 29, 2024
概括
在出生后10天内极度早产婴儿的最大体重减轻 (MWL) 与3岁时神经发育障碍 (NDI) 的风险更高有关. 过度 (>15%) 和最小 (<5%) 的MWL都与不良结果有关.
科学领域:
- 新生儿科学 新生儿科学
- 发育儿科 发育儿科
- 围产儿医学 围产儿医学
背景情况:
- 产后最大体重减轻 (MWL) 与极度早产婴儿的新生儿死亡率和发病率有关.
- 没有充分理解MWL与长期神经发育结果之间的关联.
研究的目的:
- 为了研究早期产后MWL和神经发育障碍 (NDI) 在3岁极早产婴儿之间的关系.
- 确定MWL是否是不利的神经发育结果的预测因素.
主要方法:
- 在单一中心对极度早产婴儿 (2010-2020年) 的回顾性队列研究.
- 在前10天的MWL被归类为 (>15%,5-15%,<5%).
- 主要结局:在3岁时死亡或NDI (定义为发育系数<85,脑,听力或视力障碍).
主要成果:
- 患有<5%MWL的婴儿与5-15%组相比,死亡或NDI (RR 1.36) 和NDI单独 (RR 1.43) 的风险更高.
- >15% (RR 1.32) 和<5% (RR 1.46) 的MWL组都显示出发育障碍的风险增加.
- 关联是剂量依赖的,并通过脊柱分析证实.
结论:
- 在极度早产婴儿的早期产后MWL与3岁时神经发育障碍的风险增加有关.
- 微小 (<5%) 和过度 (>15%) 的MWL都可能对神经发育结果产生负面影响.
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