在SARS-CoV-2患者的肺损伤:疫苗接种时代的尸检研究
Rossana Bussani1,2, Aldostefano Porcari3,4, Maurizio Pinamonti1
1Institute of Pathological Anatomy and Histology, Azienda Sanitaria Universitaria Giuliano-Isontina, University of Trieste, Trieste, Italy.
European journal of clinical investigation
|September 30, 2024
概括
接种COVID-19疫苗显著减少了与SARS-CoV-2相关的死亡和肺部损伤. 对1000多名已故患者的分析表明,接种疫苗可以降低死亡率并减轻肺部损伤的严重程度.
科学领域:
- 病理学 病理学 病理学
- 传染性疾病 传染性疾病
- 免疫学 免疫学 免疫学
背景情况:
- SARS-CoV-2 对肺部损伤的影响以及疫苗在减少死亡率和肺部损伤方面的有效性仍未得到充分研究.
- 了解这些影响对于公共卫生战略和患者管理至关重要.
研究的目的:
- 系统地调查SARS-CoV-2感染对肺部损伤的贡献.
- 评估疫苗接种对COVID-19死亡率和肺损伤缓解的影响.
主要方法:
- 在Trieste (2020-2022) 连续1038名死于COVID-19的住院患者的尸检分析.
- 在508个案例中进行了组织学肺损伤评估.
- 分析住院死亡率,COVID-19对死亡的贡献和疫苗接种的影响.
主要成果:
- 在90例病例中,SARS-CoV-2是主要的死亡原因,在304例病例中导致死亡,在114例病例中是偶然的.
- 作为主要死亡原因的SARS-CoV-2的发病率从2020年的23.8%下降到2022年的7.9%.
- 接种疫苗与较低的SARS-CoV-2相关死亡率 (HR 0.15,p<.001) 独立相关.
- 接种疫苗的患者 (n=172) 与未接种疫苗的患者相比 (20.3%对5.4%,p<.001) 显著减少严重的肺损伤 (肺炎严重程度得分0/1).
结论:
- 随着时间的推移,COVID-19疫苗接种显著降低了与SARS-CoV-2相关的死亡率.
- 疫苗接种证明了在COVID-19患者中减轻肺损伤的潜力.
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