预测神经内分泌前列腺癌患者的生存率:基于SEER的综合性研究
Tianlong Luo1, Jintao Hu1, Bisheng Cheng1
1Department of Urology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, China.
The world journal of men's health
|September 30, 2024
概括
新的诺基图准确预测神经内分泌前列腺癌 (NEPC) 患者的生存率. 这些工具有助于预测1年,3年和5年的整体存活率 (OS) 和癌症特异性存活率 (CSS),以便更好地规划治疗.
科学领域:
- 在瘤学瘤学.
- 泌尿器科 泌尿器科 泌尿器科 泌尿器科
- 预测模型的预测建模
背景情况:
- 神经内分泌前列腺癌 (NEPC) 是一种具有不良预后的侵袭性亚型.
- 准确的生存预测对于有效管理NEPC至关重要.
研究的目的:
- 在NEPC患者中开发和验证用于预测1年,3年和5年的整体存活率 (OS) 和癌症特异性存活率 (CSS) 的名录.
- 在NEPC中为临床决策提供可靠的预后工具.
主要方法:
- 利用来自SEER数据库的393名NEPC患者 (2010-2020) 的数据.
- 使用单变量和多变量考克斯回归分析开发了两个名图.
- 通过使用C指数,ROC曲线,校准图表和决策曲线分析验证的诺莫格拉姆表现.
主要成果:
- 诺米图表显示出强大的预测准确度,C指数为0.730-0.784.
- 确定了关键预后因素,并将其整合到模型中.
- 验证证实了开发的诺姆图的精度和临床相关性.
结论:
- 开发的诺姆图有效预测NEPC患者的生存率.
- 这些工具可以增强NEPC的临床护理和治疗计划.
- 这些名图的实施为侵袭性前列腺癌提供了量身定制的预后评估.
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