对患有2级前列腺癌的男性进行病理评估
Anika Jain1, Lawrence Kim2,3, Manish I Patel2,3,4
1Department of Urology, Western Sydney Local District, Granville, NSW, Australia. anikajain2525@gmail.com.
The world journal of men's health
|September 30, 2024
概括
一个新的策略,策略8,有效地识别了患有2级前列腺癌 (PC) 的男性,这些男性患病升级和不良结果的风险很高. 这种方法有助于局部PC的治疗决策.
科学领域:
- 泌尿器科 泌尿器科 泌尿器科 泌尿器科
- 在瘤学瘤学.
- 病理学 病理学 病理学
背景情况:
- 局部性前列腺癌 (PC) 有多种治疗选择,但对2级 (GG) 疾病的干预时间仍在争论中.
- 对于个性化治疗策略来说,识别患有GG2 PC的男性有疾病进展或不良病理结果的风险至关重要.
研究的目的:
- 开发和评估用于识别患有GG2 PC的男性,有患病升级和不良结果的风险的策略.
- 为了为局部GG2PC的治疗决策提供信息.
主要方法:
- 对243名GG2PC患者进行了回顾性分析,这些患者接受了激进前列腺切除术 (2015-2021年).
- 排除在主动监测下或接受过先前治疗 (活检,激素,放射治疗) 的患者.
- 对临床病理学数据的分析,包括前列腺特异性抗原 (PSA) 和前列腺成像报告和数据系统 (PI-RADS) 的得分.
主要成果:
- PSA和PI-RADS得分是升级的重要预测指标.
- 对于复合的不良结果,PSA,PI-RADS,前列腺外延伸,精液囊泡入侵,阳性活检核和格里森模式4体积是显著的.
- 策略8 (PI-RADS 5,高于10%的格里森模式4,或高于3个正核) 显示了与识别有升级和糟糕结果的男性的最高关联.
结论:
- 策略8是一个有价值的工具,用于治疗决策在男性GG2PC.
- 建议对策略8进行进一步验证,以确认其临床效用.
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