在非阻塞性亚子精子症男性手术精子采集后丸激素水平的变化:系统性审查和元分析
Wael Zohdy1,2, Rupin Shah2,3, Christopher Chee Kong Ho2,4
1Department of Andrology, Sexology & STIs, Faculty of Medicine, Cairo University, Cairo, Egypt.
The world journal of men's health
|September 30, 2024
概括
手术精子采集 (SSR) 显著降低了总 (TT) 在亚精子男性. 手术后的性功能障碍与阴性腺功能障碍有关,特别是在失败后的SSR或克莱因费尔特综合征.
科学领域:
- 生殖医学 生殖医学
- 安德罗学与人类学
- 内分泌学 在内分泌学.
背景情况:
- 手术精子采集 (SSR) 对于治疗患有亚精子症的男性不孕症至关重要.
- 进行SSR手术可能会造成丸损伤的风险,导致荷尔蒙失衡和降低丸激素水平.
研究的目的:
- 评估SSR对血清总 (TT),卵泡刺激激素 (FSH),黄素化激素 (LH),丸体积和性功能的影响.
主要方法:
- 进行了系统性审查和元分析 (SRMA),搜索了PubMed和Scopus的相关研究.
- 分析了17项涉及1,685名不育的阿佐精子男性的研究.
主要成果:
- 在SSR后观察到TT显著减少 (MD 3.81 nmol/L,p=0.02).
- 没有发现FSH,LH或丸体积的显著变化.
- 性功能障碍与阴性腺,抑郁和焦虑相关,特别是在未成功的SSR或Klinefelter综合征的情况下.
结论:
- SSR导致总丸激素水平显著下降.
- 术前咨询应解决性功能障碍的风险和重复SSR手术的潜在影响.
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