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Updated: May 1, 2026

A Simple, Robust, and High Throughput Single Molecule Flow Stretching Assay Implementation for Studying Transport of Molecules Along DNA
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A Simple, Robust, and High Throughput Single Molecule Flow Stretching Assay Implementation for Studying Transport of Molecules Along DNA

Published on: October 1, 2017

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通过粗粒度分子模拟,可以从数量上预测DNA的流量二重化

Isaac Pincus1, Alison Rodger2, J Ravi Prakash1

  • 1Department of Chemical and Biological Engineering, Monash University, Clayton, VIC, Australia.

Biophysical journal
|September 30, 2024
PubMed
概括

我们开发了一种多尺度的聚合物模型来预测剪切流中的DNA线性二元化 (LD). 这种计算方法准确地分离了形状和光学贡献,有助于药物标的发现.

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CD Spectroscopy to Study DNA-Protein Interactions

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Structure-Based Simulation and Sampling of Transcription Factor Protein Movements along DNA from Atomic-Scale Stepping to Coarse-Grained Diffusion

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相关概念视频

¹H NMR: Interpreting Distorted and Overlapping Signals01:02

¹H NMR: Interpreting Distorted and Overlapping Signals

Spin systems where the difference in chemical shifts of the coupled nuclei is greater than ten times J are called first-order spin systems. These nuclei are weakly coupled, and their chemical shifts and coupling constant can generally be estimated from the well-separated signals in the spectrum.
As Δν decreases and the signals move closer, the doublets appear increasingly distorted. The intensities of the inner lines increase at the cost of those of the outer lines as the signals are...
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