人类免疫缺陷病毒 (HIV-1) 通过无细胞和细胞相关感染向星球细胞
Roberta S Dos Reis1, Stephen Susa1, Marc C E Wagner1
1Department of Infectious Diseases and Microbiology, School of Public Health, University of Pittsburgh, Pittsburgh, PA 15261, USA.
Journal of integrative neuroscience
|September 30, 2024
概括
人类免疫缺陷病毒 (HIV-1) 可以感染星球细胞,可能导致HIV相关的神经认知障碍 (HAND) 中的神经毒性. 绕过正常进入路径,使星体细胞能够产生传染性HIV颗粒,这表明它们可能在中枢神经系统 (CNS) 中充当病毒储存库.
科学领域:
- 神经病毒学 神经病毒学
- 细胞生物学 细胞生物学
- 传染性疾病 传染性疾病
背景情况:
- 人类免疫缺陷病毒1型 (HIV-1) 感染天体细胞是有争议的,尽管体内有病毒DNA的证据.
- 首要的人类星体细胞被研究它们对HIV-1感染的敏感性.
研究的目的:
- 调查HIV-1感染天体细胞的潜在途径.
- 为了确定星体细胞是否可以产生传染性HIV-1颗粒.
主要方法:
- 使用来自神经发育细胞 (NPC) 和表达CXCR4和CCR5核受体的诱导多能干细胞 (iPSC) 的初级人类星体细胞.
- 星球细胞通过受感染的巨细胞/微细胞感染了细胞自由的HIV-1或细胞关联的HIV-1.
主要成果:
- 细胞自由的HIV-1显示出低水平的传染性,主要是由于进入缺陷.
- 伪型病毒绕过特定的受体进入,导致生产性天体细胞感染和释放传染性HIV-1颗粒.
结论:
- 星球细胞可能会导致艾滋病毒相关的神经认知障碍 (HAND) 的神经毒性.
- 星球细胞可以在中枢神经系统 (CNS) 中作为HIV的储存库.
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