严重脑静脉血栓瘤的内血管血栓切除术:评估安全性和疗效的综合元分析
Sherief Ghozy1,2, Atakan Orscelik1, Hatem Tolba1
1Department of Radiology, Mayo Clinic, Rochester, MN, USA.
概括
内血管治疗 (EVT) 对脑静脉血栓形成 (CSVT) 显示出有希望的结果,提供了有利的结果和良好的安全性. 建议进行进一步的研究,以比较EVT与传统医疗治疗.
科学领域:
- 神经学 神经学
- 干预性放射学 干预性放射学
- 血管医学 血管医学
背景情况:
- 大脑鼻静脉血栓形成症 (CSVT) 传统上通过全身抗凝药进行治疗.
- 内血管治疗 (EVT) 成为CSVT的潜在替代治疗方法.
- 系统审查和元分析,以评估在CSVT中EVT的疗效和安全性.
研究的目的:
- 评估EVT对CSVT的有效性.
- 在CSVT患者中评估EVT的安全性.
- 确定在EVT之后的功能结果和重新道化率.
主要方法:
- 在主要数据库 (PubMed,Embase,Scopus,Web of Science) 进行系统的文献审查.
- 包括38项研究,其中682名患者接受了CSVT的EVT治疗.
- 主要结局:修改的兰金尺度 (mRS) 0-2;次要结局:再通道化,死亡率和新/扩大血瘤的发生率.
主要成果:
- 在82.6%的患者中,有利的功能结局 (mRS 0-2).
- 再利用率高:完全的 (60.9%),部分的 (34.2%).
- 较低的死亡率 (6.7%) 和新的/扩大的血液瘤 (5.1%).
结论:
- 针对CSVT的EVT显示出良好的功能结果和重新道化率.
- EVT为CSVT治疗提供了一个有前途的安全性概况.
- 需要进行前性,比较性研究,以进一步验证EVT在CSVT管理中的作用.
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