氧气,生命的悖论和眼睛
Dario Rusciano1, Paola Bagnoli2
1Fidia Ophthalmic Research, 95123 Catania, Italy.
Frontiers in bioscience (Landmark edition)
|September 30, 2024
概括
氧化应激的基本水平对生命至关重要,因为过多的抗氧化剂会损害衰老和寿命. 本综述探讨了氧气和氧化应激的双重作用,特别是在眼睛中.
科学领域:
- 生物化学 生化学
- 细胞生物学 细胞生物学
- 眼科医生 眼科 眼科
背景情况:
- 氧化应激是由像活性氧物种 (ROS) 这样的自由基驱动的,导致与衰老和疾病相关的细胞损伤.
- 氧气对生命至关重要,但也是氧化应激的来源,当自由基的产生超过抗氧化防御时,会发生这种情况.
研究的目的:
- 审查氧气的双重作用:对生命至关重要,但是有害氧化应激的前体.
- 研究过度抗氧化剂对衰老和疾病的影响,并指出一些氧化应激对于恒温的必要性.
- 专注于眼部病理,检查氧化应激的作用和抗氧化剂缓解策略.
主要方法:
- 在PubMed和谷歌浏览器中进行了有针对性的文献搜索.
- 专注于最近的重要论文,描述氧气的双重作用和氧化应激.
- 精选了眼睛病理和抗氧化剂治疗的文献.
主要成果:
- 氧化压力对前部和后部眼部部位的病理有很大影响.
- 内源和外源抗氧化剂可以减轻眼睛疾病的发展和进展.
- 过多的抗氧化剂,就像缺乏一样,可以破坏平衡,对衰老和寿命产生负面影响.
结论:
- 基本水平的氧化应激对于维持组织和器官的平衡以及整体寿命至关重要.
- 氧化剂和抗氧化剂之间的平衡至关重要;过量的抗氧化剂可能和氧化应激一样有害.
- 需要进一步研究抗氧化剂过量在眼睛健康的背景下对抗氧化剂过量的具体影响.
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